Mre11a^tm1.1Rchd
Targeted Allele Detail

Summary

• Symbol: Mre11a^tm1.1Rchd
• Name: MRE11A homolog A, double strand break repair nuclease; targeted mutation 1.1, Stephane Richard
• MGI ID: MGI:5320419
• Synonyms: MRE11^RK
• Gene: Mre11a Location: Chr9:14695971-14748421 bp, + strand Genetic Position: Chr9, 4.33 cM
• Alliance: Mre11a^tm1.1Rchd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184053
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nine arginine residues in exon 14 were replaced with lysine (R->K) in this knock-in strain. The targeting cassette carried a loxP-flanked R->K segment, FRT site, PGK-neomycin cassette, loxP site, and FRT site. Flp-mediated recombination removed the neo cassette. (J:184053)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mre11a Mutation: 48 strains or lines available

References

• Original: J:184053 Yu Z, et al., The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation. Cell Res. 2012 Feb;22(2):305-20
• All: 1 reference(s)