Analysis Tools|
Allele Symbol Allele Name Allele ID |
Igs1+ wild type MGI:5319540 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Absence of vascular defects in the brains of embryonic day 18 Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Foxg1tm1(cre)Skm/Foxg1+
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• early postnatal lethality
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• removal of Ednrb appears to sensitize the vasculature as growth arrests proximal to the front of cre-mediated recombination
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• removal of Ednrb appears to sensitize the vasculature as growth arrests proximal to the front of cre-mediated recombination
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Spatially localized Edn2 expression results in local inhibition of retinal vascular development in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Pax6-cre,GFP)2Pgr/0 mice
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• regional thinning of all three layers in the peripheral retina
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• intraretinal capillaries are rarely seen in the peripheral retina
• numerous filopodia-bearing endothelial cells are seen at the boundary between the vascularized central retina and the nearly avascular peripheral retina
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• in the peripheral retina
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• in the peripheral retina
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• in the peripheral retina
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• intraretinal capillaries are rarely seen in the peripheral retina
• numerous filopodia-bearing endothelial cells are seen at the boundary between the vascularized central retina and the nearly avascular peripheral retina
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Interstitial tip cells in adult Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Pdgfra-cre)1Clc/0 retinas
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• intraretinal capillaries are larger and more numerous; however a large number of these terminate with blind endings
• blind endings are most numerous in the inner plexiform layer and are typically decorated with multiple filopodia
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• intraretinal capillaries are larger and more numerous; however a large number of these terminate with blind endings
• blind endings are most numerous in the inner plexiform layer and are typically decorated with multiple filopodia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Inhibition of vascular development and midgestational lethality in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Edil3Tg(Sox2-cre)1Amc/0 embryos
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• near complete absence of vascular development at E9.5
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• at E9.5-E10.5
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• pooling of blood in the head and thorax at E9.5-E10.5
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• mild growth retardation at E8.5 and severe retardation at E9.5-E10.5
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• at E9.5-E10.5
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• at E9.5-E10.5
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• mild growth retardation at E8.5 and severe retardation at E9.5-E10.5
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• at E9.5-E10.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Retinal vascular defects in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Six3-cre)69Frty/0 mice
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• some retinal regions are very thin; especially in the ganglion cell and inner nuclear layers or less commonly in the outer nuclear layer
• the peripheral retina is thinner at P6
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• in some regions few or no blood vessels are observed on the vitreal face of the retina while in other regions clusters of blood vessels occupy the vitreal face
• overall density of astrocytes and endothelial cells in the vascularized territory of this retina is several fold higher than in controls
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• many vessels in the developing retinal vascular plexus are not patent at P7 and P11 unlike in controls
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• absence of the normal intraretinal capillary beds in the inner and outer plexiform layers
• absence of vessels in the overlying the peripheral retina at P6
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• some regions are very thin
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• some regions are very thin
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• not as common as in the inner nuclear and ganglion cell layers
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• regions of extensive detachment with numerous macrophages in the subretinal space, severe folding of the retina, accumulation of interstitial fluid, and/or development of interstitial fibrosis
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• interstitial fibrosis is seen in some regions
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• severe folding of the retina
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• in some regions few or no blood vessels are observed on the vitreal face of the retina while in other regions clusters of blood vessels occupy the vitreal face
• overall density of astrocytes and endothelial cells in the vascularized territory of this retina is several fold higher than in controls
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• many vessels in the developing retinal vascular plexus are not patent at P7 and P11 unlike in controls
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• absence of the normal intraretinal capillary beds in the inner and outer plexiform layers
• absence of vessels in the overlying the peripheral retina at P6
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• modest delay in the expansion of the astrocyte front in the developing retina at P3-P6 that is gone by P8
• endothelial cell growth is significantly retarded at all postnatal ages with the radial position of the growing endothelial cells largely arrested by P6
• filopodia-bearing endothelial cells are seen throughout much of the vascular plexus in the retina instead of being located predominantly in the growing front
• large excess of tip cells in the developing retinal vascular plexus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Absence of vascular defects in the skin of adult Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(KRT5-cre)5132Jlj/0 mice
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• massive increase in dermal pigmentation
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• massive increase in dermal pigmentation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 01/06/2026 MGI 6.24 |
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