Phenotypes associated with this allele

• Allele Symbol: Was^tm1.1Ldn
• Allele Name: targeted mutation 1.1, Luigi D Notarangelo
• Allele ID: MGI:5319483
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd79a^tm1(cre)Reth/Cd79a^+ Was^tm1.1Ldn/Was^tm1.1Ldn	involves: BALB/c * C57BL/6	MGI:5319484
cn2	Cd79a^tm1(cre)Reth/Cd79a^+ Was^tm1.1Ldn/Y	involves: BALB/c * C57BL/6	MGI:5319485
cn3	Cd79a^tm1(cre)Reth/Cd79a^+ Was^tm1.1Ldn/Was^+	involves: BALB/c * C57BL/6	MGI:5319486

Genotype
MGI:5319484

cn1

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺; Was^tm1.1Ldn/Was^tm1.1Ldn
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased germinal center B cell number ( J:182528 )

♀ • in the spleen and lymph nodes

increased plasma cell number ( J:182528 )

♀ • increase in the proportion of CD19+ CD138^hi plasma cells

decreased B cell number ( J:182528 )

♀ • B cell lymphopenia

decreased mature B cell number ( J:182528 )

♀ • decrease in the percentage and absolute number of bone marrow B220 hi mature recirculating B cells

♀ • decrease in the proportion and number of CD19+ B cells in the spleen

decreased follicular B cell number ( J:182528 )

♀ • decrease in absolute number but not the proportion of follicular B cells

decreased marginal zone B cell number ( J:182528 )

♀ • decrease in the percentage and absolute number of marginal zone B cells

♀ • the ring of B220+ CD1d+ MZ B cells that normally surrounds MOMA-expressing metallophilic macrophages is almost absent

abnormal B cell physiology ( J:182528 )

♀ • virtual abrogation of IgM and IgG pneumococcus polysaccharide specific Ab responses

♀ • abrogation of the early response to immunization with UV inactivated vesicular stomatitis virus

increased IgM level ( J:182528 )

♀ • elevated total serum levels and spontaneous production of IgM Abs specific for trinitrophenyl and phosphocholine

increased autoantibody level ( J:182528 )

♀

increased anti-chromatin antibody level ( J:182528 )

♀

increased anti-double stranded DNA antibody level ( J:182528 )

♀

increased anti-single stranded DNA antibody level ( J:182528 )

♀

renal/urinary system

abnormal renal corpuscle morphology ( J:182528 )

♀ • modest degree of glomerular damage

hematopoietic system

increased germinal center B cell number ( J:182528 )

♀ • in the spleen and lymph nodes

increased plasma cell number ( J:182528 )

♀ • increase in the proportion of CD19+ CD138^hi plasma cells

decreased B cell number ( J:182528 )

♀ • B cell lymphopenia

decreased mature B cell number ( J:182528 )

♀ • decrease in the percentage and absolute number of bone marrow B220 hi mature recirculating B cells

♀ • decrease in the proportion and number of CD19+ B cells in the spleen

decreased follicular B cell number ( J:182528 )

♀ • decrease in absolute number but not the proportion of follicular B cells

decreased marginal zone B cell number ( J:182528 )

♀ • decrease in the percentage and absolute number of marginal zone B cells

♀ • the ring of B220+ CD1d+ MZ B cells that normally surrounds MOMA-expressing metallophilic macrophages is almost absent

abnormal B cell physiology ( J:182528 )

♀ • virtual abrogation of IgM and IgG pneumococcus polysaccharide specific Ab responses

♀ • abrogation of the early response to immunization with UV inactivated vesicular stomatitis virus

increased IgM level ( J:182528 )

♀ • elevated total serum levels and spontaneous production of IgM Abs specific for trinitrophenyl and phosphocholine

Genotype
MGI:5319485

cn2

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺; Was^tm1.1Ldn/Y
• Genetic Background: involves: BALB/c * C57BL/6

immune system

increased germinal center B cell number ( J:182528 )

♂ • in the spleen and lymph nodes

increased plasma cell number ( J:182528 )

♂ • increase in the proportion of CD19+ CD138^hi plasma cells

decreased B cell number ( J:182528 )

♂ • B cell lymphopenia

decreased mature B cell number ( J:182528 )

♂ • decrease in the percentage and absolute number of bone marrow B220 hi mature recirculating B cells

♂ • decrease in the proportion and number of CD19+ B cells in the spleen

decreased follicular B cell number ( J:182528 )

♂ • decrease in absolute number but not the proportion of follicular B cells

decreased marginal zone B cell number ( J:182528 )

♂ • decrease in the percentage and absolute number of marginal zone B cells

♂ • the ring of B220+ CD1d+ MZ B cells that normally surrounds MOMA-expressing metallophilic macrophages is almost absent

abnormal B cell physiology ( J:182528 )

♂ • virtual abrogation of IgM and IgG pneumococcus polysaccharide specific Ab responses

♂ • abrogation of the early response to immunization with UV inactivated vesicular stomatitis virus

increased IgM level ( J:182528 )

♂ • elevated total serum levels and spontaneous production of IgM Abs specific for trinitrophenyl and phosphocholine

increased autoantibody level ( J:182528 )

♂

increased anti-chromatin antibody level ( J:182528 )

♂

increased anti-double stranded DNA antibody level ( J:182528 )

♂

increased anti-single stranded DNA antibody level ( J:182528 )

♂

renal/urinary system

abnormal renal corpuscle morphology ( J:182528 )

♂ • modest degree of glomerular damage

hematopoietic system

increased germinal center B cell number ( J:182528 )

♂ • in the spleen and lymph nodes

increased plasma cell number ( J:182528 )

♂ • increase in the proportion of CD19+ CD138^hi plasma cells

decreased B cell number ( J:182528 )

♂ • B cell lymphopenia

decreased mature B cell number ( J:182528 )

♂ • decrease in the percentage and absolute number of bone marrow B220 hi mature recirculating B cells

♂ • decrease in the proportion and number of CD19+ B cells in the spleen

decreased follicular B cell number ( J:182528 )

♂ • decrease in absolute number but not the proportion of follicular B cells

decreased marginal zone B cell number ( J:182528 )

♂ • decrease in the percentage and absolute number of marginal zone B cells

♂ • the ring of B220+ CD1d+ MZ B cells that normally surrounds MOMA-expressing metallophilic macrophages is almost absent

abnormal B cell physiology ( J:182528 )

♂ • virtual abrogation of IgM and IgG pneumococcus polysaccharide specific Ab responses

♂ • abrogation of the early response to immunization with UV inactivated vesicular stomatitis virus

increased IgM level ( J:182528 )

♂ • elevated total serum levels and spontaneous production of IgM Abs specific for trinitrophenyl and phosphocholine

Genotype
MGI:5319486

cn3

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺; Was^tm1.1Ldn/Was⁺
• Genetic Background: involves: BALB/c * C57BL/6

immune system

abnormal B cell proliferation ( J:182528 )

♀ • increased proliferation in cells lacking expression of Was compared to cells expressing Was in the follicular and germinal center B cell populations

abnormal B cell number ( J:182528 )

♀ • while B cell numbers are similar to controls, the distribution of cells lacking expression of Was is biased against marginal zone B cells

♀ • enrichment of null cells in the germinal center cell and plasma cell populations

hematopoietic system

abnormal B cell proliferation ( J:182528 )

♀ • increased proliferation in cells lacking expression of Was compared to cells expressing Was in the follicular and germinal center B cell populations

abnormal B cell number ( J:182528 )

♀ • while B cell numbers are similar to controls, the distribution of cells lacking expression of Was is biased against marginal zone B cells

♀ • enrichment of null cells in the germinal center cell and plasma cell populations

cellular

abnormal B cell proliferation ( J:182528 )

♀ • increased proliferation in cells lacking expression of Was compared to cells expressing Was in the follicular and germinal center B cell populations