Phenotypes associated with this allele

• Allele Symbol: Ntrk1^tm2.1Lfr
• Allele Name: targeted mutation 2.1, Louis F Reichardt
• Allele ID: MGI:5319087
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ntrk1^tm2.1Lfr/Ntrk1^tm2.1Lfr Tg(dlx5a-cre)1Mekk/0	involves: 129 * C57BL/6 * CD-1 * SJL	MGI:5319088

Genotype
MGI:5319088

cn1

• Allelic Composition: Ntrk1^tm2.1Lfr/Ntrk1^tm2.1Lfr; Tg(dlx5a-cre)1Mekk/0
• Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal innervation ( J:183467 )

• impaired cholinergic innervation into the frontal cortex at P7

• decrease in cholinergic fiber density and absence of a clear laminar pattern of innervation in the hippocampus at P14

• complete absence of cholinergic fibers in the hippocampus and only a small number of fibers in the frontal cortex at P90

behavior/neurological

abnormal behavior ( J:183467 )

• measurable decline in amygdala-dependent, but not hippocampal-dependent, cognitive performance

impaired cued conditioning behavior ( J:183467 )

abnormal response to novel object ( J:183467 )

• significant decrease in recognition of a novel object