Phenotypes associated with this allele

• Allele Symbol: Tamalin^tm1.1Tes
• Allele Name: targeted mutation 1.1, Lino Tessarollo
• Allele ID: MGI:5318549
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tamalin^tm1.1Tes/Tamalin^tm1.1Tes	B6.129S1-Tamalin^tm1.1Tes	MGI:5318558

Genotype
MGI:5318558

hm1

• Allelic Composition: Tamalin^tm1.1Tes/Tamalin^tm1.1Tes
• Genetic Background: B6.129S1-Tamalin^tm1.1Tes

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:181614 )

N • mice exhibit normal hippocampal synaptic plasticity following electroconvulsive shock

abnormal neuron differentiation ( J:181614 )

• mice exhibit blunted electroconvulsive shock-induced neurogenesis compared with wild-type mice

• neurons exhibit impaired electroconvulsive shock-induced mossy fiber sprouting and granule cell dendritic arborization compared with wild-type neurons

abnormal neuron proliferation ( J:181614 )

• mice exhibit blunted electroconvulsive shock-induced neurogenesis compared with wild-type mice

abnormal excitatory postsynaptic potential ( J:181614 )

• following electroconvulsive shock, the input-output curve reaches the maximal field excitatory postsynaptic potential amplitude compared with wild-type mice

reduced long-term potentiation ( J:181614 )

• following electroconvulsive shock, 1 h long term potential is almost completely abolished unlike in wild-type mice that exhibit a slight reduction

cellular

abnormal neuron differentiation ( J:181614 )

• mice exhibit blunted electroconvulsive shock-induced neurogenesis compared with wild-type mice

• neurons exhibit impaired electroconvulsive shock-induced mossy fiber sprouting and granule cell dendritic arborization compared with wild-type neurons

abnormal neuron proliferation ( J:181614 )

• mice exhibit blunted electroconvulsive shock-induced neurogenesis compared with wild-type mice