Analysis Tools
mortality/aging
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• most mice die at P1, which could not be prevented by Caesarean delivery
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homeostasis/metabolism
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• mice exhibit increased lactate tolerance compared with wild-type mice
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• in mice fed a high cholic acid diet
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• in mice fed a high fat diet or standard chow
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• in mice fed a high fat diet or standard chow
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• in mice fed a high fat diet
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• in mice fed standard chow (at 50 weeks), a high cholesterol diet, a high fat, sucrose and cholesterol diet or a high cholic acid diet
• however, mice fed a high fat diet are protected from liver damage
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• in mice fed standard chow, a high cholesterol diet, a high fat, sucrose and cholesterol diet or a high cholic acid diet
• however, treatment with 9-cis-RA reduces alkaline phosphatase level
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• in mice fed standard chow
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• in mice fed a high fat diet, a high fat, sucrose and cholesterol diet or a high cholic acid diet
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• in mice fed a high fat diet or standard chow
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• during the dark phase but not the light phase when fed a high fat diet or standard chow
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• in fasting mice fed a high fat diet or standard chow
• however, treatment with 9-cis-RA enables mice to maintain their blood glucose after fasting
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• in mice fed a high fat diet or standard chow
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• in mice fed a high cholic acid diet
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• in mice fed a high cholic acid diet
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• LDL-triglyceride in mice fed a high fat diet with high sucrose and cholesterol
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• in the serum of mice fed standard chow, a high cholesterol diet, a high fat, sucrose and cholesterol diet, or high cholic acid diet
• in the liver of mice fed a high cholesterol or a high fat, sucrose and cholesterol diet
• however, treatment with 9-cis-RA reduces bile acid levels
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• when fed a high fat diet, mice exhibit a decrease in the ratio of LDL-cholesterol to HDL-cholesterol compared with wild-type mice
• in mice fed a high fat, sucrose and cholesterol diet, the ratio of LDL-cholesterol to HDL-cholesterol is reversed compared to in wild-type mice
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• in mice fed a high fat diet, standard chow or high fat, sucrose and cholesterol diet
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• in mice fed a high cholesterol diet or a high fat, sucrose and cholesterol diet
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• in mice fed a high fat diet or a high fat, sucrose and cholesterol diet
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• in mice fed a high cholesterol diet or a high cholic acid diet
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• in mice fed standard chow, a high fat diet, a high fat, sucrose and cholesterol diet or a high cholesterol diet
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• mice exhibit higher levels of free retinol compared with wild-type mice
• however, treatment with 9-cis-RA reduce levels of free retinol
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liver/biliary system
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• a good amount of bilesand is found in the gallbladders of mice fed a high cholic acid diet
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• the gall bladders of mice fed a high cholic acid diet exhibit hyperplastic mucosal epithelia unlike in wild-type mice
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• in mice fed a high cholic acid diet
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• the livers of mice fed a high cholesterol diet exhibit surface asperity and turn yellow with enhanced formation of dilated canalicular structure compared to wild-type livers
• the livers of mice fed a high fat, sucrose and cholesterol diet exhibit small dilated canalicular structure compared to wild-type livers
• the livers of mice fed a high cholic acid diet are yellow-brown unlike in wild-type mice
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• in mice fed a high fat diet or a high fat, sucrose and cholesterol diet
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• in mice fed a high cholesterol diet or a high cholic acid diet
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• in mice fed standard chow, a high fat diet, a high fat, sucrose and cholesterol diet or a high cholesterol diet
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• mice fed a high cholic acid diet exhibit hypertrophic hepatocytes with lipid droplets unlike wild-type mice
• mice exhibit abnormal hepatocytes with variable size and numerous multinucleated hepatocytes unlike in wild-type mice
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• in mice fed a high fat diet or standard chow
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• in mice fed a high fat, sucrose and cholesterol diet
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cholestasis
(
J:183827
)
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• embryonic
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• bile juice is light in color in mice fed a high cholic acid diet
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• significantly reduced levels of cholesterol and phospholipids in bile juice of mice fed a high cholic acid diet
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adipose tissue
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• in mice fed a high fat diet or standard chow
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• in mice fed a high fat diet or standard chow
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• preadipocytes exhibit increased capacity to differentiate into adipocytes compared with wild-type cells
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• in mice fed a high fat diet or standard chow
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• in mice fed a high fat diet or standard chow
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• in mice fed a high fat diet or standard chow
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endocrine/exocrine glands
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• a good amount of bilesand is found in the gallbladders of mice fed a high cholic acid diet
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• the gall bladders of mice fed a high cholic acid diet exhibit hyperplastic mucosal epithelia unlike in wild-type mice
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• in mice fed a high cholic acid diet
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• in mice fed a high fat diet or standard chow
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growth/size/body
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• in mice fed a high cholic acid diet
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• in mice fed a high fat diet or standard chow
• however, treatment with 9-cis-RA exhibit weight gain
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• in mice fed a high fat diet, a high fat, sucrose and cholesterol diet or a high cholic acid diet
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behavior/neurological
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• in mice fed standard chow
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cellular
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• preadipocytes exhibit increased capacity to differentiate into adipocytes compared with wild-type cells
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integument
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• in mice fed a high fat diet or standard chow
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renal/urinary system
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• in mice fed a high fat diet or standard chow
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