Analysis Tools
behavior/neurological
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• in an open field test
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• in a tube test
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• mice do not walk on a rotarod as long as wild-type mice
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• in a partition test, mice exhibit increased social interest compared with wild-type mice
• in a direct social interaction test, mice are more active social than wild-type mice
• in a three chamber apparatus, mice spend more time in the social chamber compared with wild-type mice
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nervous system
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• in female, but not male, mice
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• reduced
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• mice exhibit an increase in the number of neurons in layer V of the somatosensory cortex compared with wild-type mice
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craniofacial
| N |
• mice exhibit normal teeth morphology
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• longer skull in male mice than in wild-type mice
• however, female skull length is almost normal
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growth/size/body
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• from P1 to P5 onward
• more severe in male mice than in female mice
• mice are more affected that mice carrying Del(5Limk1-Trim50)2Uta but less so than mice carrying Del(5Gtf2i-Limk1)1Uta Del(5Limk1-Trim50)2Uta
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cardiovascular system
| N |
• abdominal aortic wall motion is normal
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skeleton
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• longer skull in male mice than in wild-type mice
• however, female skull length is almost normal
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