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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cigs2tm1.1Anse
targeted mutation 1.1, K Mark Ansel
MGI:5313809
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cigs2tm1.1Anse/Cigs2tm1.1Anse involves: BALB/cJ * C57BL/6 MGI:5314000
cx2
 		Cigs2tm1.1Anse/Cigs2+
Il4tm1(CD2)Mmrs/Il4+ 		involves: 129 * BALB/cJ * C57BL/6 MGI:5313999


Genotype
MGI:5314000
hm1
Allelic
Composition		 Cigs2tm1.1Anse/Cigs2tm1.1Anse
Genetic
Background		 involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:181313 )
• IgE switching is abolished following exposure to ovalbumin
abnormal humoral immune response ( J:181313 )
• following exposure to ovalbumin, type 2 responses are reduced (pulmonary resistance, numbers of eosinophils and lymphocytes in bronchoalveolar lavage fluid and IgE switching) compared with wild-type mice
• mice exposed to Leishmania exhibit decreased IgE, decreased IgG1 and increased IgG2b compared with wild-type mice
• however, ovalbumin-exposed mice exhibit normal peribronchial and perivascular inflammatory infiltrates and mucus hypersecretion typical of allergic inflammation and normal footpad swelling and Leishmania-exposed mice exhibit normal parasite titer in response to
decreased IgE level ( J:181313 )
• following exposure to ovalbumin
decreased IgG1 level ( J:181313 )
• in response to Leishmania exposure
increased IgG2b level ( J:181313 )
• in response to Leishmania exposure
decreased interleukin-13 secretion ( J:181313 )
• in Th2 polarized CD4+ T cells
decreased interleukin-4 secretion ( J:181313 )
• in Th2 polarized CD4+ T cells
• in restimulated T cells in the draining popliteal lymph nodes of mice exposed to Leishmania
abnormal susceptibility to infection ( J:181313 )
• mice exposed to Leishmania exhibit decreased IgE, decreased IgG1 and increased IgG2b compared with wild-type mice
• however, mice exhibit normal footpad swelling and parasite titer

respiratory system
decreased airway resistance ( J:181313 )
• following exposure to ovalbumin

hematopoietic system
abnormal class switch recombination ( J:181313 )
• IgE switching is abolished following exposure to ovalbumin
decreased IgE level ( J:181313 )
• following exposure to ovalbumin
decreased IgG1 level ( J:181313 )
• in response to Leishmania exposure
increased IgG2b level ( J:181313 )
• in response to Leishmania exposure




Genotype
MGI:5313999
cx2
Allelic
Composition		 Cigs2tm1.1Anse/Cigs2+
Il4tm1(CD2)Mmrs/Il4+
Genetic
Background		 involves: 129 * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cigs2tm1.1Anse mutation (0 available); any Cigs2 mutation (0 available)
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:181313 )
N
• following intraperitoneal injection of ovalbumin, mice exhibit normal IgG2b response compared with Il4tm1(CD2)Mmrs heterozygotes
• T cells and basophils exhibit normal Il13 production
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation
decreased IgE level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
decreased IgG1 level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
decreased interleukin-4 secretion ( J:181313 )
• in Th2 polarized CD4+ T cells compared with Il4tm1(CD2)Mmrs heterozygotes
• in parathymic lymph node and lung-draining mediastinal node T cells from mice injected with ovalbumin
• in T cells and basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation

hematopoietic system
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation
decreased IgE level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
decreased IgG1 level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory