Analysis Tools
adipose tissue
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• mammary adipose cells, the majority of which normally would be replaced by mammary gland epithelial (ME) cells in late pregnancy, continue to constitute a significant part of the mammary gland during late pregnancy and postpartum
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endocrine/exocrine glands
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• pregnant transgenic mice exhibit premature mammary gland epithelial (ME) cell proliferation, driven by constitutive expression of cyclin D1
• the normal replacement of the majority of mammary adipose cells by ME cells during late pregnacy and postpartum fails to occur
• pregnant female mice with this transgene do not exhibit the late-pregnancy and postpartum ME cell apoptosis observed in large T-antigen transgenic mice
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• in pregnant female mice with this transgene, mammary gland expression of the small t-antigen inhibits development of the normal alveolar and ductal network
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• in pregnant female mice with this transgene, mammary gland expression of the small t-antigen inhibits development of the normal alveolar and ductal network
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• 12% (5/41) of multiparous (2-3 pregnancies) female transgenic mice develop t-antigen positive mammary adenomcarcinomas, most as single tumors in inguinal or axillary glands, with latencies of 10-17 months
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• milk production is very low, necessitating fostering of the pups
• expression of the whey acidic protein (WAP) mRNA is demonstrable by RT-PCR analysis, but the protein is not detectable by immunoblot analysis
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integument
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• pregnant transgenic mice exhibit premature mammary gland epithelial (ME) cell proliferation, driven by constitutive expression of cyclin D1
• the normal replacement of the majority of mammary adipose cells by ME cells during late pregnacy and postpartum fails to occur
• pregnant female mice with this transgene do not exhibit the late-pregnancy and postpartum ME cell apoptosis observed in large T-antigen transgenic mice
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• in pregnant female mice with this transgene, mammary gland expression of the small t-antigen inhibits development of the normal alveolar and ductal network
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|
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• in pregnant female mice with this transgene, mammary gland expression of the small t-antigen inhibits development of the normal alveolar and ductal network
|
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• 12% (5/41) of multiparous (2-3 pregnancies) female transgenic mice develop t-antigen positive mammary adenomcarcinomas, most as single tumors in inguinal or axillary glands, with latencies of 10-17 months
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• milk production is very low, necessitating fostering of the pups
• expression of the whey acidic protein (WAP) mRNA is demonstrable by RT-PCR analysis, but the protein is not detectable by immunoblot analysis
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reproductive system
neoplasm
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• 12% (5/41) of multiparous (2-3 pregnancies) female transgenic mice develop t-antigen positive mammary adenomcarcinomas, most as single tumors in inguinal or axillary glands, with latencies of 10-17 months
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