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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm3(Runx2)Flng
targeted mutation 3, Fanxin Long
MGI:5311032
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng involves: 129X1/SvJ MGI:5311111
cn2
 		Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng
Ihhtm1Amc/Ihhtm1Amc
Tg(Col2a1-cre)3Amc/0 		involves: 129S1/Sv * 129X1/SvJ MGI:5311114
cn3
 		Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng
Runx2tm1Mjo/Runx2tm1Mjo
Tg(Col2a1-cre)3Amc/0 		involves: 129X1/SvJ MGI:5311112
cn4
 		Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sor+
Runx2tm1Mjo/Runx2tm1Mjo
Tg(Col2a1-cre)3Amc/0 		involves: 129X1/SvJ MGI:5311113


Genotype
MGI:5311111
hm1
Allelic
Composition		 Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(Runx2)Flng mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:180304 )
• mice are completely normal




Genotype
MGI:5311114
cn2
Allelic
Composition		 Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng
Ihhtm1Amc/Ihhtm1Amc
Tg(Col2a1-cre)3Amc/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(Runx2)Flng mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Ihhtm1Amc mutation (1 available); any Ihh mutation (22 available)
Tg(Col2a1-cre)3Amc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal long bone epiphyseal plate morphology ( J:180304 )
• the nonhypertrophic chondrocyte zone in the tibia is reduced to a greater extent than in Ihhtm1Amc homozygotes
abnormal long bone hypertrophic chondrocyte zone ( J:180304 )
• hypertrophic chondrocytes exhibit accelerated progression from early stage to late stage hypertrophy compared with control mice
abnormal bone structure ( J:180304 )
• thin bone collar

cellular




Genotype
MGI:5311112
cn3
Allelic
Composition		 Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng
Runx2tm1Mjo/Runx2tm1Mjo
Tg(Col2a1-cre)3Amc/0
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(Runx2)Flng mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Runx2tm1Mjo mutation (0 available); any Runx2 mutation (42 available)
Tg(Col2a1-cre)3Amc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:180304 )
N
• unlike Runx2tm1Mjo homozygotes, mice exhibit normal cartilage, bone collar, and marrow and restored osteoblast differentiation and cartilage hypertrophy
abnormal bone ossification ( J:180304 )
• at E18.5, bone formation defects observed in Runx2tm1Mjo homozygotes are partially recovered in the endochondrial skeleton but not the skull




Genotype
MGI:5311113
cn4
Allelic
Composition		 Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sor+
Runx2tm1Mjo/Runx2tm1Mjo
Tg(Col2a1-cre)3Amc/0
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(Runx2)Flng mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Runx2tm1Mjo mutation (0 available); any Runx2 mutation (42 available)
Tg(Col2a1-cre)3Amc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:180304 )
N
• unlike Runx2tm1Mjo homozygotes, mice exhibit normal bone collar
abnormal bone marrow cavity morphology ( J:180304 )
• like Runx2tm1Mjo homozygotes, mice lack a marrow cavity
abnormal bone ossification ( J:180304 )
• at E18.5, bone formation defects observed in Runx2tm1Mjo homozygotes are partially recovered in the endochondrial skeleton but not the skull




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory