About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Panx2tm1.1Mony
targeted mutation 1.1, Hannah Monyer
MGI:5310802
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Panx2tm1.1Mony/Panx2tm1.1Mony involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5311016
cx2
 		Panx1tm1.1Fama/Panx1tm1.1Fama
Panx2tm1.1Mony/Panx2tm1.1Mony 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5311017
cx3
 		Panx1tm1.1Fama/Panx1+
Panx2tm1.1Mony/Panx2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5311018


Genotype
MGI:5311016
hm1
Allelic
Composition		 Panx2tm1.1Mony/Panx2tm1.1Mony
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx2tm1.1Mony mutation (0 available); any Panx2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased susceptibility to ischemic brain injury ( J:180516 )
• in a stroke model using middle cerebral artery occlusion, mice exhibit decreased neurological deficits (latency to move) compared with wild-type mice
• however, infarct size is normal

nervous system
decreased susceptibility to ischemic brain injury ( J:180516 )
• in a stroke model using middle cerebral artery occlusion, mice exhibit decreased neurological deficits (latency to move) compared with wild-type mice
• however, infarct size is normal




Genotype
MGI:5311017
cx2
Allelic
Composition		 Panx1tm1.1Fama/Panx1tm1.1Fama
Panx2tm1.1Mony/Panx2tm1.1Mony
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx1tm1.1Fama mutation (1 available); any Panx1 mutation (37 available)
Panx2tm1.1Mony mutation (0 available); any Panx2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Panx1tm1.1Fama/Panx1tm1.1Fama Panx2tm1.1Mony/Panx2tm1.1Mony mice are protected in a stroke model

nervous system
decreased susceptibility to ischemic brain injury ( J:180516 )
• in a stroke model using middle cerebral artery occlusion, mice exhibit decreased neurological deficits (right turns and latency to move) and infarct volume size compared with wild-type mice
• however, mice exhibit normal production of mature IL1B in cerebral ischemia
abnormal channel response ( J:180516 )
• neuron dye release to measure channel function is completely blocked unlike in wild-type cells
• however, mice exhibit normal channel function in astrocytes and cortical spreading depolarization

homeostasis/metabolism
decreased susceptibility to ischemic brain injury ( J:180516 )
• in a stroke model using middle cerebral artery occlusion, mice exhibit decreased neurological deficits (right turns and latency to move) and infarct volume size compared with wild-type mice
• however, mice exhibit normal production of mature IL1B in cerebral ischemia




Genotype
MGI:5311018
cx3
Allelic
Composition		 Panx1tm1.1Fama/Panx1+
Panx2tm1.1Mony/Panx2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx1tm1.1Fama mutation (1 available); any Panx1 mutation (37 available)
Panx2tm1.1Mony mutation (0 available); any Panx2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal channel response ( J:180516 )
• neuron dye release to measure channel function is slightly decreased compared to in wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory