All Phenotypes Slc6a3<tm1.1Jaja> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc6a3^tm1.1Jaja
targeted mutation 1.1, Jonathan A Javitch
MGI:5310749

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc6a3^tm1.1Jaja/Slc6a3^tm1.1Jaja	B6.129-Slc6a3^tm1.1Jaja	MGI:5310793

Allelic Composition	Slc6a3^tm1.1Jaja/Slc6a3^tm1.1Jaja
Genetic Background	B6.129-Slc6a3^tm1.1Jaja

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a3^tm1.1Jaja mutation (0 available); any Slc6a3 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:180517 )

N	• mice exhibit normal survival rate

reproductive system

reproductive system phenotype ( J:180517 )

N	• mice exhibit normal lactation

nervous system

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:180517 )

• mice are resistant to paraquat-induced dopamine neuron neurotoxicity but decreased dopamine levels compared with wild-type mice

homeostasis/metabolism

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:180517 )

• mice are resistant to paraquat-induced dopamine neuron neurotoxicity but decreased dopamine levels compared with wild-type mice

decreased dopamine level ( J:180517 )

• in paraquat-treated mice

cellular

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:180517 )

• mice are resistant to paraquat-induced dopamine neuron neurotoxicity but decreased dopamine levels compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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