Slc6a3^tm1.1Jaja
Targeted Allele Detail

Summary

• Symbol: Slc6a3^tm1.1Jaja
• Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1.1, Jonathan A Javitch
• MGI ID: MGI:5310749
• Gene: Slc6a3 Location: Chr13:73684866-73726791 bp, + strand Genetic Position: Chr13, 40.1 cM
• Alliance: Slc6a3^tm1.1Jaja page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180517
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Hypomorph) Mutations: Insertion, Nucleotide substitutions Mutation details: This hypomorphic allele was generated by nucleotide substitution in exon 2 that results in the amino acid substitution of alanine for serine at positions 2, 4, 7, 12 and 13(S2A/S4A/S7A/S12A/S13A). Cre-mediated recombination removed the floxed neo cassette inserted upstream of the translation start site in exon 2. (J:180517)

Generation of the Slc6a3^tm1.1Jaja hypomorphic allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a3 Mutation: 66 strains or lines available

References

• Original: J:180517 Rappold PM, et al., Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20766-71
• All: 1 reference(s)