About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnni3tm1.1Jdp
targeted mutation 1.1, James Potter
MGI:5308372
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnni3tm1.1Jdp/Tnni3tm1.1Jdp involves: 129S6/SvEvTac * C57BL/6 MGI:5308375


Genotype
MGI:5308375
hm1
Allelic
Composition		 Tnni3tm1.1Jdp/Tnni3tm1.1Jdp
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnni3tm1.1Jdp mutation (0 available); any Tnni3 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Cardiac hypertrophy in Tnni3tm1.1Jdp/Tnni3tm1.1Jdp hearts

mortality/aging
mortality/aging ( J:180606 )
N
• homozygous mice live at least 18 months

cardiovascular system
cardiovascular system phenotype ( J:180606 )
N
• cardiac morphology is normal at 3 and 6 months of age
thick interventricular septum ( J:180606 )
• by 12 months of age
increased heart weight ( J:180606 )
• heart/body weight ratio is increased by 12 months of age
thick ventricular wall ( J:180606 )
• increased left ventricle wall thickness at 12 mongths of age
cardiac interstitial fibrosis ( J:180606 )
• pronounced interstitial fibrosis by 12 months of age

growth/size/body
increased heart weight ( J:180606 )
• heart/body weight ratio is increased by 12 months of age

cellular
cardiac interstitial fibrosis ( J:180606 )
• pronounced interstitial fibrosis by 12 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory