Tnni3^tm1.1Jdp
Targeted Allele Detail

Summary

• Symbol: Tnni3^tm1.1Jdp
• Name: troponin I, cardiac 3; targeted mutation 1.1, James Potter
• MGI ID: MGI:5308372
• Synonyms: R21C+
• Gene: Tnni3 Location: Chr7:4521304-4526228 bp, - strand Genetic Position: Chr7, 2.61 cM
• Alliance: Tnni3^tm1.1Jdp page

Cardiac hypertrophy in Tnni3^tm1.1Jdp/Tnni3^tm1.1Jdp hearts

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180606
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Dominant negative, Humanized sequence, Inserted expressed sequence) Mutation: Insertion Mutation details: A C to T transition in codon 21 changed the encoded amino acid from arginine to cysteine. In addition, a floxed neo cassette was inserted in intron 3. Subsequent cre-mediated excision removed the neo selection cassette. (J:180606)

Generation of the Tnni3^tm1Jdp and Tnni3^tm1.1Jdp alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnni3 Mutation: 17 strains or lines available

References

• Original: J:180606 Wang Y, et al., Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy. J Biol Chem. 2012 Jan 13;287(3):2156-67
• All: 3 reference(s)