Phenotypes associated with this allele

• Allele Symbol: Grin2b^{tm1.1(Grin2a)Bjha}
• Allele Name: targeted mutation 1.1, Benjamin J Hall
• Allele ID: MGI:5307054
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2b^tm1.1(Grin2a)Bjha/Grin2b^tm1.1(Grin2a)Bjha	involves: 129S6/SvEvTac * C57BL/6	MGI:5307057

Genotype
MGI:5307057

hm1

• Allelic Composition: Grin2b^{tm1.1(Grin2a)Bjha}/Grin2b^{tm1.1(Grin2a)Bjha}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:178913 )

• only about 8% of mice survive past P0

behavior/neurological

abnormal suckling behavior ( J:178913 )

• at P0 a decrease in the number of rhythmic mouth suckling movements in response to stimulation with a feeding needle is seen

• lack of milk in the stomach at P0

increased locomotor activity ( J:178913 )

• increased spontaneous locomotion at P15-P21

abnormal social/conspecific interaction behavior ( J:178913 )

• interact less frequently with their littermates than control animals

abnormal social investigation ( J:178913 )

• in a social approach assay mice spend less time exploring the bottle containing the mouse

social withdrawal ( J:178913 )

growth/size/body

decreased body size ( J:178913 )

• at P12-P16 but not at P0

nervous system

abnormal AMPA-mediated synaptic currents ( J:178913 )

• significant increase in mean mEPSC amplitudes

abnormal NMDA-mediated synaptic currents ( J:178913 )

• NMDA evoked currents in neurons are insensitive to ifenprodil and are more sensitive to zinc ions

• significantly faster decay times

abnormal miniature excitatory postsynaptic currents ( J:178913 )