Grin2b^{tm1.1(Grin2a)Bjha}
Targeted Allele Detail

Summary

• Symbol: Grin2b^{tm1.1(Grin2a)Bjha}
• Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 1.1, Benjamin J Hall
• MGI ID: MGI:5307054
• Synonyms: 2B->2A
• Gene: Grin2b Location: Chr6:135690231-136150509 bp, - strand Genetic Position: Chr6, 66.38 cM
• Alliance: Grin2b^{tm1.1(Grin2a)Bjha} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178913
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4, the first coding exon, was replaced with the a cDNA encoding for rat Grin2a and a loxP site flanked neomycin resistance gene cassette via homologous recombination. Cre mediated recombination removed the neo cassette. Western blot analysis indicates premature expression of Grin2a and absence of expression of Grin2b in homozygous mice. (J:178913)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin2b Mutation: 96 strains or lines available

References

• Original: J:178913 Wang CC, et al., A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function. Neuron. 2011 Dec 8;72(5):789-805
• All: 1 reference(s)