All Phenotypes Lgals12<tm1Ftl> MGI Mouse

homeostasis/metabolism phenotype ( J:180097 )

N	• mice exhibit normal serum glycerol and fatty acid • mice exhibit normal hepatic and muscle lipid content

increased energy expenditure ( J:180097 )

• indicated by increased oxygen consumption

increased oxygen consumption ( J:180097 )

• in whole mouse and adipocytes

improved glucose tolerance ( J:180097 )

• in mice weighing more than 30 g

increased insulin sensitivity ( J:180097 )

• in mice weighing more than 30 g

abnormal hormone level ( J:180097 )

• decreased leptin in adipose tissue

increased circulating insulin level ( J:180097 )

• in mice weighing more than 30 g after glucose injection

decreased circulating leptin level ( J:180097 )

abnormal free fatty acids level ( J:180097 )

• basal free fatty acid release from adipocytes is increased compared to in wild-type mice

increased glycerol level ( J:180097 )

• basal glycerol release from adipocytes is increased compared to in wild-type mice

• adipocytes treated with denosine deaminase (ADA) and increasing concentrations of (-)-N6-(2-Phenylisopropyl)adenosine (PIA) or rolipram and/or cilostamide exhibit increased glycerol release compared with wild-type cells

• however, isoproterenol-induced lipolysis in adipocytes is normally suppressed by insulin treatment

decreased triglyceride level ( J:180097 )

• in the epididymal fat pad of mice fed a standard diet

enhanced lipolysis ( J:180097 )

• 2-fold in adipocytes

• in adipocytes stimulated with isoproterenol

• however, isoproterenol-induced lipolysis in adipocytes is normally suppressed by insulin treatment

adipose tissue phenotype ( J:180097 )

N	• mice exhibit normal numbers of adipocytes

decreased brown adipose tissue mass ( J:180097 )

• in mice fed a standard diet

decreased white fat cell size ( J:180097 )

• in the epididymal fat pad of mice fed a standard diet

decreased epididymal fat pad weight ( J:180097 )

• in mice fed a standard diet

• in fasted mice fed a high-fat diet

decreased inguinal fat pad weight ( J:180097 )

• in mice fed a standard diet

• in fasted mice fed a high-fat diet

decreased percent body fat/body weight ( J:180097 )

• in mice fed a standard diet

abnormal white adipose tissue physiology ( J:180097 )

• adipocytes exhibit enhanced basal and stimulated lipolysis

• basal glycerol and free fatty acid release from adipocytes is increased compared to in wild-type mice

• adipocytes treated with denosine deaminase (ADA) and increasing concentrations of (-)-N6-(2-Phenylisopropyl)adenosine (PIA) or rolipram and/or cilostamide exhibit increased glycerol release compared with wild-type cells

• however, isoproterenol-induced lipolysis in adipocytes is normally suppressed by insulin treatment

growth/size/body region phenotype ( J:180097 )

N	• mice exhibit normal body weight on standard chow or a high-fat diet

increased percent water in carcass ( J:180097 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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