Phenotypes associated with this allele

• Allele Symbol: Tdrd7^tm1.1Chum
• Allele Name: targeted mutation 1.1, Shinichiro Chuma
• Allele ID: MGI:5305937
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tdrd7^tm1.1Chum/Tdrd7^tm1.1Chum	involves: 129S6/SvEvTac * C57BL/6	MGI:5305957
cx2	Tdrd6^tm1Chum/Tdrd6^tm1Chum Tdrd7^tm1.1Chum/Tdrd7^tm1.1Chum	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5305959

Genotype
MGI:5305957

hm1

• Allelic Composition: Tdrd7^tm1.1Chum/Tdrd7^tm1.1Chum
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Haploid spermatid defect in Tdrd7^tm1.1Chum/Tdrd7^tm1.1Chum mice

reproductive system

small testis ( J:173550 )

♂

arrest of spermatogenesis ( J:173550 )

♂ • at round spermatid stage

♂ • spermatid impairment before nuclear condensation stage

♂ • unusual chromatoid bodies seen

abnormal male reproductive system physiology ( J:173550 )

♂

increased male germ cell apoptosis ( J:173550 )

♂ • increased apoptosis of round spermatids

male infertility ( J:173550 )

♂

vision/eye

optic nerve degeneration ( J:173550 )

• glaucoma is observed

endocrine/exocrine glands

small testis ( J:173550 )

♂

cellular

increased male germ cell apoptosis ( J:173550 )

♂ • increased apoptosis of round spermatids

nervous system

optic nerve degeneration ( J:173550 )

• glaucoma is observed

Genotype
MGI:5305959

cx2

• Allelic Composition: Tdrd6^tm1Chum/Tdrd6^tm1Chum; Tdrd7^tm1.1Chum/Tdrd7^tm1.1Chum
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Initial assembly of chromatoid bodies is disrupted in Tdrd6^tm1Chum/Tdrd6^tm1Chum Tdrd7^tm1.1Chum/Tdrd7^tm1.1Chum mice

reproductive system

arrest of spermatogenesis ( J:173550 )

♂ • at round spermatid stage

♂ • chromatoid bodies completely absent from early assembly stage in spermatocytes to late stage haploid spermatids

male infertility ( J:173550 )

♂