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Allele Symbol Allele Name Allele ID |
Igk-Jtm1.1Lave targeted mutation 1.1, Laurent Verkoczy MGI:5305129 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• B cell development is partially rescued
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• B cell development is partially rescued
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• modest blockage at the pro/large pre-B to small pre-B transition
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• mice exhibit increased clonal deletion compared with control mice
• however, clonal deletion is rescued by culturing immature sIg+ B cells in vitro with IL17 followed by BAFF (TNFSF13B) or in vitro culture of a population of 2F5 bnAb-producing naive sIg+ bone marrow B cells
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• more severe than in Igh-Jtm1.1Lave homozygotes
(J:179317)
• B cell development is blocked at the small pre-B to immature B transition
(J:205708)
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• in the bone marrow, spleen, lymph node, and Preyer's patch
(J:179317)
• in the bone marrow
(J:205708)
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• B cells exhibit elevated basal activation and muted response to BCR ligation
|
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• mice exhibit lower immunoglobulin densities that is more severe than in Igh-Jtm1.1Lave homozygotes
|
|
• modest blockage at the pro/large pre-B to small pre-B transition
|
|
• mice exhibit increased clonal deletion compared with control mice
• however, clonal deletion is rescued by culturing immature sIg+ B cells in vitro with IL17 followed by BAFF (TNFSF13B) or in vitro culture of a population of 2F5 bnAb-producing naive sIg+ bone marrow B cells
|
|
• more severe than in Igh-Jtm1.1Lave homozygotes
(J:179317)
• B cell development is blocked at the small pre-B to immature B transition
(J:205708)
|
|
• in the bone marrow, spleen, lymph node, and Preyer's patch
(J:179317)
• in the bone marrow
(J:205708)
|
|
• B cells exhibit elevated basal activation and muted response to BCR ligation
|
|
• mice exhibit lower immunoglobulin densities that is more severe than in Igh-Jtm1.1Lave homozygotes
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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