Phenotypes associated with this allele

• Allele Symbol: Spint1^tm2.1Hk
• Allele Name: targeted mutation 2.1, Hiroaki Kataoka
• Allele ID: MGI:5304850
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Spint1^tm2.1Hk/Spint1^tm2.1Hk Tg(Vil1-cre)997Gum/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:5304853

Genotype
MGI:5304853

cn1

• Allelic Composition: Spint1^tm2.1Hk/Spint1^tm2.1Hk; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:179937 )

• in DSS-treated mice

digestive/alimentary system

abnormal large intestine crypts of Lieberkuhn morphology ( J:179937 )

• mice exhibit dissolution of crypt architecture with reduced crypt size and crypt disorganization unlike in control mice

intestinal ulcer ( J:179937 )

• cecum ulcers in DSS-treated mice

small cecum ( J:179937 )

• in DSS-treated mice

abnormal defecation ( J:179937 )

• bloody stool in DSS-treated mice

diarrhea ( J:179937 )

• in DSS-treated mice

abnormal intestine physiology ( J:179937 )

• mice exhibit increased intestinal permeability compared with control mice

increased enterocyte apoptosis ( J:179937 )

• in colon, suggested by increased epithelial cell shedding

abnormal enterocyte proliferation ( J:179937 )

• increased in the colon

increased susceptibility to induced colitis ( J:179937 )

• DSS-treated mice exhibit delayed mucosal regeneration, short cecum length, cecum ulceration, more severe diarrhea, bloody stool, increased weight loss, and increased mortality compared with control mice

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:179937 )

• in DSS-treated mice

immune system

increased susceptibility to induced colitis ( J:179937 )

• DSS-treated mice exhibit delayed mucosal regeneration, short cecum length, cecum ulceration, more severe diarrhea, bloody stool, increased weight loss, and increased mortality compared with control mice

cellular

increased enterocyte apoptosis ( J:179937 )

• in colon, suggested by increased epithelial cell shedding

abnormal enterocyte proliferation ( J:179937 )

• increased in the colon

growth/size/body

increased susceptibility to weight loss ( J:179937 )

• in DSS-treated mice

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:179937 )

• mice exhibit dissolution of crypt architecture with reduced crypt size and crypt disorganization unlike in control mice