Phenotypes associated with this allele

• Allele Symbol: Egln3^tm1Vlcg
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:5304712
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Egln1^tm1Kael/Egln1^tm1Kael Egln3^tm1Vlcg/Egln3^tm1Vlcg Tg(Myh6-cre)2182Mds/0	involves: 129S6/SvEvTac * FVB/N	MGI:5304713

Genotype
MGI:5304713

cn1

• Allelic Composition: Egln1^tm1Kael/Egln1^tm1Kael; Egln3^tm1Vlcg/Egln3^tm1Vlcg; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:179490 )

• mean survival is 29 weeks

cardiovascular system

increased angiogenesis ( J:179490 )

myocardial fiber degeneration ( J:179490 )

increased heart weight ( J:179490 )

• at 5 weeks and severe at 8 weeks

abnormal heart left ventricle morphology ( J:179490 )

• at 8 weeks, mice exhibit reduced left ventricular wall thickness and increased left ventricular end-diastolic dimension compared with control mice

decreased ventricle muscle contractility ( J:179490 )

• at 5 weeks and severe at 8 weeks

cardiomyopathy ( J:179490 )

• severe at 8 weeks of age

muscle

myocardial fiber degeneration ( J:179490 )

decreased ventricle muscle contractility ( J:179490 )

• at 5 weeks and severe at 8 weeks

cardiomyopathy ( J:179490 )

• severe at 8 weeks of age

cellular

decreased mitochondrial number ( J:179490 )

• myocytes exhibit mitochondrial loss

growth/size/body

increased heart weight ( J:179490 )

• at 5 weeks and severe at 8 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cardiomyopathy		DOID:0050700		J:179490