All Phenotypes Del(14Trim13-Rnaseh2b)6Rdf MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Del(14Trim13-Rnaseh2b)6Rdf
deletion, Chr 14, Riccardo Dalla-Favera 6
MGI:5304666

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(14Trim13-Rnaseh2b)6Rdf/Del(14Trim13-Rnaseh2b)6Rdf	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:5305093
cn2	Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:5305095
cn3	Del(14Trim13-Rnaseh2b)6Rdf/+ Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:5305096

Allelic Composition	Del(14Trim13-Rnaseh2b)6Rdf/Del(14Trim13-Rnaseh2b)6Rdf
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:179879 )

Allelic Composition	Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Del(14Trim13-Rnaseh2b)6Rdf mutation (0 available); any Del(14Trim13-Rnaseh2b)6Rdf mutation (0 available)
Is(14)1Rdf mutation (0 available); any Is(14)1Rdf mutation (0 available)
Is(14)5Rdf mutation (1 available); any Is(14)5Rdf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179879 )

neoplasm

increased chronic lymphocytic leukemia incidence ( J:179879 )

increased lymphoma incidence ( J:179879 )

• mice develop B cell clonal lymphoproliferations, chronic lymphocytic leukemia , small cell lymphomas, and CD5- non-Hodgkin lymphomas

increased small lymphocytic lymphoma incidence ( J:179879 )

immune system

abnormal lymphopoiesis ( J:179879 )

• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220^lo) with characteristics of chronic lymphocytic leukemia

• 42% of mice develop clonal lymphoproliferations

increased B cell number ( J:179879 )

• IgM+CD5+B220^lo

hematopoietic system

abnormal lymphopoiesis ( J:179879 )

• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220^lo) with characteristics of chronic lymphocytic leukemia

• 42% of mice develop clonal lymphoproliferations

increased B cell number ( J:179879 )

• IgM+CD5+B220^lo

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:179879

Allelic Composition	Del(14Trim13-Rnaseh2b)6Rdf/+ Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179879 )

• 70% of mice die by 20 months

neoplasm

increased chronic lymphocytic leukemia incidence ( J:179879 )

increased lymphoma incidence ( J:179879 )

• mice develop B cell clonal lymphoproliferations, chronic lymphocytic leukemia , small cell lymphomas, and CD5- non-Hodgkin lymphomas

increased small lymphocytic lymphoma incidence ( J:179879 )

immune system

abnormal lymphopoiesis ( J:179879 )

• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220^lo) with characteristics of chronic lymphocytic leukemia

• 25% of mice develop clonal lymphoproliferations

increased B cell number ( J:179879 )

• IgM+CD5+B220^lo

hematopoietic system

abnormal lymphopoiesis ( J:179879 )

• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220^lo) with characteristics of chronic lymphocytic leukemia

• 25% of mice develop clonal lymphoproliferations

increased B cell number ( J:179879 )

• IgM+CD5+B220^lo

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:179879

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/07/2025 MGI 6.24