Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Pdss2tm1.1Jdhu mutation
(0 available);
any
Pdss2 mutation
(31 available)
Pdss2tm1.2Jdhu mutation
(0 available);
any
Pdss2 mutation
(31 available)
Tg(Pcp2-cre)3555Jdhu mutation
(1 available)
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behavior/neurological
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• at 9.5 months, mice exhibit failure in motor coordination during walking and incapability to maintain balance on a rod
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• mice exhibit shorter and more variable strides with more frequent additional steps made by both forepaw and hindpaw compared with wild-type mice
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nervous system
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• at 6 months in the cerebellum
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• in the cerebellum of aged mice
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• at 6 months in the cerebellum
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cellular
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• at 6 months in the cerebellum
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdss2tm1.1Jdhu mutation
(0 available);
any
Pdss2 mutation
(31 available)
Pdss2tm1.2Jdhu mutation
(0 available);
any
Pdss2 mutation
(31 available)
Tg(Pax2-cre)1Akg mutation
(2 available)
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mortality/aging
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• all mice die within 36 hours of life
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nervous system
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• at E14.5, mice exhibit ectopic apoptosis accompanying the progression of cerebellum hypoplasia
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• at E12.5, radial glial cells in the cerebellum are fewer in number and have shorter processes compared to in wild-type mice
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• fewer radial glial cells in the cerebellum at E12.5
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• neurons are highly compacted close to the ventricular surface and leave the dorsal region devoid of cells unlike in wild-type mice
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• small midbrain at E17.5
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• hypoplasia is more severe at the vermis (midline region) than in cerebellar hemispheres
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• cell stratification is disorganized
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• cerebellum growth retardation begins at E12.5 and E14.5 due to decreased cell proliferation, increased ectopic apoptosis (beginning at E14.5), and impaired expansion of cerebellum volume
• at E14.5, expansion of the intermediate zone is delayed compared to in wild-type mice
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• at E12.5, the subventricular zone has fewer and disorganized cells above the proliferating cell layers compared to in wild-type mice
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craniofacial
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• palatine shelves retain a vertical position and fail to fuse along the midline
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behavior/neurological
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• in mice with normal palates
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muscle
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• at P0, lipid accumulates in the forelimb skeletal muscle
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respiratory system
cellular
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• at E18.5, cells of the cerebellum exhibit abnormal mitochondrial and autophagic-like vacuoles compared to in wild-type mice
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• in cells of the cerebellum
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• at E14.5, mice exhibit ectopic apoptosis accompanying the progression of cerebellum hypoplasia
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• at E12.5, radial glial cells in the cerebellum are fewer in number and have shorter processes compared to in wild-type mice
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• fewer radial glial cells in the cerebellum at E12.5
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• neurons are highly compacted close to the ventricular surface and leave the dorsal region devoid of cells unlike in wild-type mice
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skeleton
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• palatine shelves retain a vertical position and fail to fuse along the midline
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digestive/alimentary system
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• palatine shelves retain a vertical position and fail to fuse along the midline
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growth/size/body
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• palatine shelves retain a vertical position and fail to fuse along the midline
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Analysis Tools