All Phenotypes Ccne1<tm3.1Pisc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ccne1^tm3.1Pisc/Ccne1^tm3.1Pisc Ccne2^tm1Pisc/Ccne2^tm1Pisc	involves: 129S2/SvPas	MGI:5304329
cn2	Ccne1^tm3.1Pisc/Ccne1^tm3.1Pisc Ccne2^tm1Pisc/Ccne2^tm1Pisc Tg(Nes-cre)1Kln/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:5304330

Allelic Composition	Ccne1^tm3.1Pisc/Ccne1^tm3.1Pisc Ccne2^tm1Pisc/Ccne2^tm1Pisc
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1^tm3.1Pisc mutation (0 available); any Ccne1 mutation (22 available)
Ccne2^tm1Pisc mutation (0 available); any Ccne2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dendritic spine morphology ( J:178882 )

• hippocampal slices transfected with cre exhibit decreased dendritic spine numbers compared with control neurons

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:178882 )

N	• mice exhibit normal proliferation rates throughout embryonic brain development, numbers of proliferating progenitor cells in the subventricular zone, and numbers of neural stem/progenitor cells

abnormal dendritic spine morphology ( J:178882 )

• adult mice exhibit reduced spine length, width, and estimated spine volume compared with control mice

abnormal postsynaptic density morphology ( J:178882 )

• in the CA1 stratum radiatum, neurons exhibit reduced length of postsynaptic densities compared with control neurons

decreased excitatory postsynaptic current frequency ( J:178882 )

• spontaneous excitatory postsynaptic current frequency in CA1 pyramidal neurons is reduced compared to in control neurons

abnormal excitatory postsynaptic potential ( J:178882 )

• field excitatory postsynaptic potential amplitude and slope are decreased compared to in control mice

reduced NMDA-mediated synaptic currents ( J:178882 )

reduced long-term potentiation ( J:178882 )

behavior/neurological

abnormal spatial learning ( J:178882 )

• mice exhibit impaired performance in a Morris water maze and spatial reversal learning compared with control mice

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