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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccne1tm3.1Pisc
targeted mutation 3.1, Piotr Sicinski
MGI:5304324
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ccne1tm3.1Pisc/Ccne1tm3.1Pisc
Ccne2tm1Pisc/Ccne2tm1Pisc 		involves: 129S2/SvPas MGI:5304329
cn2
 		Ccne1tm3.1Pisc/Ccne1tm3.1Pisc
Ccne2tm1Pisc/Ccne2tm1Pisc
Tg(Nes-cre)1Kln/0 		involves: 129S2/SvPas * C57BL/6 * SJL MGI:5304330


Genotype
MGI:5304329
cn1
Allelic
Composition		 Ccne1tm3.1Pisc/Ccne1tm3.1Pisc
Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm3.1Pisc mutation (0 available); any Ccne1 mutation (23 available)
Ccne2tm1Pisc mutation (0 available); any Ccne2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendritic spine morphology ( J:178882 )
• hippocampal slices transfected with cre exhibit decreased dendritic spine numbers compared with control neurons




Genotype
MGI:5304330
cn2
Allelic
Composition		 Ccne1tm3.1Pisc/Ccne1tm3.1Pisc
Ccne2tm1Pisc/Ccne2tm1Pisc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm3.1Pisc mutation (0 available); any Ccne1 mutation (23 available)
Ccne2tm1Pisc mutation (0 available); any Ccne2 mutation (32 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:178882 )
N
• mice exhibit normal proliferation rates throughout embryonic brain development, numbers of proliferating progenitor cells in the subventricular zone, and numbers of neural stem/progenitor cells
abnormal dendritic spine morphology ( J:178882 )
• adult mice exhibit reduced spine length, width, and estimated spine volume compared with control mice
abnormal postsynaptic density morphology ( J:178882 )
• in the CA1 stratum radiatum, neurons exhibit reduced length of postsynaptic densities compared with control neurons
decreased excitatory postsynaptic current frequency ( J:178882 )
• spontaneous excitatory postsynaptic current frequency in CA1 pyramidal neurons is reduced compared to in control neurons
abnormal excitatory postsynaptic potential ( J:178882 )
• field excitatory postsynaptic potential amplitude and slope are decreased compared to in control mice

behavior/neurological
abnormal spatial learning ( J:178882 )
• mice exhibit impaired performance in a Morris water maze and spatial reversal learning compared with control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory