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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Crx-cre/ERT2)1Tfur
transgene insertion 1, Takahisa Furukawa
MGI:5302219
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Raxtm1.1Tfur/Raxtm1.1Tfur
Tg(Crx-cre/ERT2)1Tfur/0 		involves: 129S6/SvEvTac * C3H * C57BL/6 MGI:5311350
cn2
 		Nmnat1tm1c(EUCOMM)Wtsi/Nmnat1tm1c(EUCOMM)Wtsi
Tg(Crx-cre/ERT2)1Tfur/0 		involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N MGI:6272876


Genotype
MGI:5311350
cn1
Allelic
Composition		 Raxtm1.1Tfur/Raxtm1.1Tfur
Tg(Crx-cre/ERT2)1Tfur/0
Genetic
Background		 involves: 129S6/SvEvTac * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raxtm1.1Tfur mutation (1 available); any Rax mutation (16 available)
Tg(Crx-cre/ERT2)1Tfur mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina hypoplasia ( J:177908 )
• retina size at E15.5 is significantly smaller than wild type




Genotype
MGI:6272876
cn2
Allelic
Composition		 Nmnat1tm1c(EUCOMM)Wtsi/Nmnat1tm1c(EUCOMM)Wtsi
Tg(Crx-cre/ERT2)1Tfur/0
Genetic
Background		 involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmnat1tm1c(EUCOMM)Wtsi mutation (0 available); any Nmnat1 mutation (34 available)
Tg(Crx-cre/ERT2)1Tfur mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
retina photoreceptor degeneration ( J:267630 )
• by P28, most photoreceptor cells are degenerated and the outer nuclear layer is absent in the retina

vision/eye
abnormal retina morphology ( J:267630 )
• retinal lamination defects are seen at P6
retina photoreceptor degeneration ( J:267630 )
• by P28, most photoreceptor cells are degenerated and the outer nuclear layer is absent in the retina
retina outer nuclear layer degeneration ( J:267630 )
• progressive thinning of the outer nuclear layer
decreased total retina thickness ( J:267630 )
• reduction in overall retinal thickness is apparent by P15




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory