Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl1tm1Lix mutation
(0 available);
any
Elavl1 mutation
(43 available)
Tg(Scgb1a1-rtTA)2Jaw mutation
(1 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
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immune system
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• reduced pulmonary inflammation in mice treated with doxycycline and intranasal rIL17
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• reduced pulmonary inflammation in mice treated with doxycycline and intranasal rIL17
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respiratory system
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• reduced pulmonary inflammation in mice treated with doxycycline and intranasal rIL17
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Scgb1a1-rtTA)2Jaw mutation
(1 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
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mortality/aging
N |
• doxycycline-treated mice do not exhibit perinatal toxicity
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respiratory system
N |
• doxycycline-treated mice do not exhibit lung pathology or dysfunction
• doxycycline-treated mice exhibit minimal focal airspace enlargement unlike Tg(Scgb1a1-rtTA)1Jaw mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1.1Wesh mutation
(0 available);
any
Adam17 mutation
(62 available)
Tg(Scgb1a1-rtTA)2Jaw mutation
(1 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
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mortality/aging
N |
• doxycycline-treated mice exhibit normal neonatal survival
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respiratory system
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• reduced pulmonary capillary formation in doxycycline-treated mice
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• at E18.5, doxycycline-treated mice exhibit reduced terminal sacs and thickened surrounding mesenchyme in the peripheral lung compared with control mice
• larger but fewer sacs at P1 in doxycycline-treated mice
• however, morphology at P14 and P30 is normal
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• at E18.5 in doxycycline-treated mice
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• impaired epithelial cell differentiation in doxycycline-treated mice
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cellular
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• at P1, but not P30, in the lungs of doxycycline-treated mice
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cardiovascular system
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• reduced pulmonary capillary formation in doxycycline-treated mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1.1Wesh mutation
(0 available);
any
Adam17 mutation
(62 available)
Tg(Scgb1a1-rtTA)2Jaw mutation
(1 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
Twist2tm1.1(cre)Dor mutation
(1 available);
any
Twist2 mutation
(10 available)
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mortality/aging
N |
• doxycycline-treated mice exhibit normal neonatal survival
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respiratory system
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• reduced pulmonary capillary formation in doxycycline-treated mice
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• doxycycline-treated mice exhibit enlarged airspaces with fewer number of saccules and reduced epithelial cell differentiation compared with control mice
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cellular
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• in the lungs of doxycycline-treated mice
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cardiovascular system
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• reduced pulmonary capillary formation in doxycycline-treated mice
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