Phenotypes associated with this allele

• Allele Symbol: Cop1^{Gt(XR0653)1.1Wtsi}
• Allele Name: gene trap XR0653, 1.1 Welcome Trust Sanger Institute
• Allele ID: MGI:5301600
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cop1^Gt(XR0653)1.1Wtsi/Cop1^Gt(XR0653)1.1Wtsi	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5301610
ht2	Cop1^Gt(XR0653)Wtsi/Cop1^Gt(XR0653)1.1Wtsi	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5301609

Genotype
MGI:5301610

hm1

• Allelic Composition: Cop1^{Gt(XR0653)1.1Wtsi}/Cop1^{Gt(XR0653)1.1Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:178271 )

• 15-20% reduction in body weight of both sexes through 40 days of age

• organ size reduced as well with no obvious defects

pigmentation

belly spot ( J:178271 )

• ventral white spotting

neoplasm

increased tumor incidence ( J:178271 )

• spontaneous tumor development is seen in about 50% of homozygotes

increased testicular teratoma incidence ( J:178271 )

♂

increased T cell derived lymphoma incidence ( J:178271 )

• predominant tumor type to appear

increased B cell derived lymphoma incidence ( J:178271 )

increased histiocytic sarcoma incidence ( J:178271 )

increased incidence of induced tumors ( J:178271 )

• aggressive lymphomas develop 14-30 weeks after radiation treatment

increased uterus tumor incidence ( J:178271 )

♀ • anaplastic uterine tumor

integument

belly spot ( J:178271 )

• ventral white spotting

endocrine/exocrine glands

increased testicular teratoma incidence ( J:178271 )

♂

increased T cell derived lymphoma incidence ( J:178271 )

• predominant tumor type to appear

reproductive system

increased testicular teratoma incidence ( J:178271 )

♂

increased uterus tumor incidence ( J:178271 )

♀ • anaplastic uterine tumor

Genotype
MGI:5301609

ht2

• Allelic Composition: Cop1^{Gt(XR0653)Wtsi}/Cop1^{Gt(XR0653)1.1Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:178271 )

• most die by E15.5

hematopoietic system

anemia ( J:178271 )

• develops after E12.5

homeostasis/metabolism

hydrops fetalis ( J:178271 )

• develops after E12.5