Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oscartm1Ywc mutation
(1 available);
any
Oscar mutation
(22 available)
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skeleton
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• TGFB1-treated bone marrow macrophage immobilized on a minimal hOSCAR-binding triple-helical peptide (OSCpep) fail to exhibit an increate in giant TRAP+ osteoclasts unlike similarly treated wild-type cells
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cellular
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• TGFB1-treated bone marrow macrophage immobilized on a minimal hOSCAR-binding triple-helical peptide (OSCpep) fail to exhibit an increate in giant TRAP+ osteoclasts unlike similarly treated wild-type cells
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hematopoietic system
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• TGFB1-treated bone marrow macrophage immobilized on a minimal hOSCAR-binding triple-helical peptide (OSCpep) fail to exhibit an increate in giant TRAP+ osteoclasts unlike similarly treated wild-type cells
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immune system
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• TGFB1-treated bone marrow macrophage immobilized on a minimal hOSCAR-binding triple-helical peptide (OSCpep) fail to exhibit an increate in giant TRAP+ osteoclasts unlike similarly treated wild-type cells
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skeleton
N |
• mice exhibit normal osteoblast parameters
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• mice exhibit decreased osteoclast number and size compared with Tyrobptm1Ttk homozygotes
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• TGFB1-treated bone marrow macrophage immobilized on a minimal hOSCAR-binding triple-helical peptide (OSCpep) fail to exhibit an increate in giant TRAP+ osteoclasts unlike similarly treated cells from Tyrobptm1Ttk homozygotes
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• compared with Tyrobptm1Ttk homozygotes
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• mice exhibit a reduction in eroded bone surface compared with Tyrobptm1Ttk homozygotes
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• mice exhibit increased bone trabecula number, increased trabecular bone volume, and decreased trabecular space compared with Tyrobptm1Ttk homozygotes
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• compared with Tyrobptm1Ttk homozygotes
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• compared with Tyrobptm1Ttk homozygotes
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cellular
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• TGFB1-treated bone marrow macrophage immobilized on a minimal hOSCAR-binding triple-helical peptide (OSCpep) fail to exhibit an increate in giant TRAP+ osteoclasts unlike similarly treated cells from Tyrobptm1Ttk homozygotes
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hematopoietic system
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• mice exhibit decreased osteoclast number and size compared with Tyrobptm1Ttk homozygotes
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• TGFB1-treated bone marrow macrophage immobilized on a minimal hOSCAR-binding triple-helical peptide (OSCpep) fail to exhibit an increate in giant TRAP+ osteoclasts unlike similarly treated cells from Tyrobptm1Ttk homozygotes
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• compared with Tyrobptm1Ttk homozygotes
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• mice exhibit a reduction in eroded bone surface compared with Tyrobptm1Ttk homozygotes
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immune system
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• mice exhibit decreased osteoclast number and size compared with Tyrobptm1Ttk homozygotes
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• TGFB1-treated bone marrow macrophage immobilized on a minimal hOSCAR-binding triple-helical peptide (OSCpep) fail to exhibit an increate in giant TRAP+ osteoclasts unlike similarly treated cells from Tyrobptm1Ttk homozygotes
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• compared with Tyrobptm1Ttk homozygotes
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• mice exhibit a reduction in eroded bone surface compared with Tyrobptm1Ttk homozygotes
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