All Phenotypes Tln1<tm1.1Bpet> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tln1^tm1.1Bpet
targeted mutation 1.1, Brian G Petrich
MGI:5299185

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tln1^tm1.1Bpet/Tln1^tm4.1Crit Tg(Pf4-icre)Q3Rsko/0	involves: 129P2/OlaHsd * C57BL/6	MGI:5299187

Allelic Composition	Tln1^tm1.1Bpet/Tln1^tm4.1Crit Tg(Pf4-icre)Q3Rsko/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pf4-icre)Q3Rsko mutation (1 available)
Tln1^tm1.1Bpet mutation (0 available); any Tln1 mutation (145 available)
Tln1^tm4.1Crit mutation (2 available); any Tln1 mutation (145 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal platelet physiology ( J:177971 )

• fibrogen binding is reduced compared to wild-type cells

• platelets exhibit defective agonist induced platelet integrin activation compared with wild-type mice

• however, binding in the presence of manganese is normal

reduced thrombolysis ( J:177971 )

• clot retraction is impaired compared to in wild-type mice

• however, clot retraction in the presence of manganese is normal

hematopoietic system

abnormal platelet physiology ( J:177971 )

• fibrogen binding is reduced compared to wild-type cells

• platelets exhibit defective agonist induced platelet integrin activation compared with wild-type mice

• however, binding in the presence of manganese is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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