Tln1^tm1.1Bpet
Targeted Allele Detail

Summary

• Symbol: Tln1^tm1.1Bpet
• Name: talin 1; targeted mutation 1.1, Brian G Petrich
• MGI ID: MGI:5299185
• Synonyms: Tln1^L325R
• Gene: Tln1 Location: Chr4:43531513-43562583 bp, - strand Genetic Position: Chr4, 23.05 cM
• Alliance: Tln1^tm1.1Bpet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177971
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 10 was replaced with one in which a point mutation results in the amino acid substitution of leucine with arginine at position 325 (p.L325R) in the encoded protein. A loxP site flanked neomycin resistance gene cassette that was inserted into intron 10 was removed by subsequent cre-mediated recombination. (J:177971)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tln1 Mutation: 145 strains or lines available

References

• Original: J:177971 Haling JR, et al., Talin-dependent integrin activation is required for fibrin clot retraction by platelets. Blood. 2011 Feb 3;117(5):1719-22
• All: 6 reference(s)