About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dppa4tm1Yam
targeted mutation 1, Shinya Yamanaka
MGI:5298638
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Dppa2tm1Yam/Dppa2tm1Yam
Dppa4tm1Yam/Dppa4tm1Yam 		involves: 129S4/SvJae MGI:5298647
cx2
 		Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1Yam/Dppa4tm1Yam 		involves: 129S4/SvJae MGI:5298648


Genotype
MGI:5298647
cx1
Allelic
Composition		 Dppa2tm1Yam/Dppa2tm1Yam
Dppa4tm1Yam/Dppa4tm1Yam
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2tm1Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4tm1Yam mutation (1 available); any Dppa4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:178324 )
• viable and fertile with no gross abnormalities




Genotype
MGI:5298648
cx2
Allelic
Composition		 Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1Yam/Dppa4tm1Yam
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2tm1.1Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4tm1Yam mutation (1 available); any Dppa4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:178324 )
• cyanotic pups die within 2h of birth

respiratory system
respiratory failure ( J:178324 )
• seen in pups that die within 2h of birth

homeostasis/metabolism
cyanosis ( J:178324 )
• displayed by some pups

cellular
decreased cell proliferation ( J:178324 )
• slower proliferation of cultured embryonic stem cells compared to controls
abnormal DNA methylation ( J:178324 )
• methylation status of some genes is altered in cultured embryonic stem cells compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory