Analysis Tools
behavior/neurological
| N |
• mice exhibit normal righting reflex, whisker touch reflex, ear twitch reflex, activity in an open field test, anxiety-related behavior in a novel environment or in an elevated plus maze, performance in a wire hang test, learning and memory performance in an eight-arm radial maze test, and circadian rhythms
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• in a Barnes circular maze, acquisition of spatial reference memory is impaired compared with wild-type mice
• however, consolidation and retention are normal
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• mildly improved spatial working memory only in the task with no delay in a T maze
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• in a light-dark test, mice exhibit fewer transition into the light section compared with wild-type mice
• however, other tests for anxiety-related behavior are normal
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• in an open field test
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• induced by MK-801
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• induced by MK-801
• however, spontaneous locomotor activity is normal
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• duration of contact is increased compared to wild-type mice
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growth/size/body
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• 10% less
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homeostasis/metabolism
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• MK-801-treated mice exhibit increased horizontal and vertical activity compared with wild-type mice
• however, time spent in the center of the area is normal
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nervous system
| N |
• mice exhibit normal long term potentiation
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