Phenotypes associated with this allele

• Allele Symbol: Tnfsf11^tm1.2Htaka
• Allele Name: targeted mutation 1.2, Hiroshi Takayanagi
• Allele ID: MGI:5297062
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfsf11^tm1.2Htaka/Tnfsf11^tm1.2Htaka	B6.Cg-Tnfsf11^tm1.2Htaka	MGI:5297087
ht2	Tnfsf11^tm1.2Htaka/Tnfsf11^+	B6.Cg-Tnfsf11^tm1.2Htaka	MGI:5297088
cn3	Tnfsf11^tm1.1Htaka/Tnfsf11^tm1.2Htaka Tg(Lck-cre)1Cwi/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:5297085
cn4	Tnfsf11^tm1.1Htaka/Tnfsf11^tm1.2Htaka Tg(Dmp1-cre)1Jqfe/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N	MGI:5297086

Genotype
MGI:5297087

hm1

• Allelic Composition: Tnfsf11^tm1.2Htaka/Tnfsf11^tm1.2Htaka
• Genetic Background: B6.Cg-Tnfsf11^tm1.2Htaka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

failure of tooth eruption ( J:177557 )

decreased osteoclast cell number ( J:177557 )

• not detected

abnormal long bone metaphysis morphology ( J:177557 )

• enlarged

decreased length of long bones ( J:177557 )

kyphosis ( J:177557 )

increased bone volume ( J:177557 )

abnormal trabecular bone morphology ( J:177557 )

• trabecular separation is decreased compared to in wild-type mice

osteopetrosis ( J:177557 )

abnormal cartilage morphology ( J:177557 )

• mice exhibit cartilage remnants unlike wild-type mice

decreased bone resorption ( J:177557 )

growth/size/body

failure of tooth eruption ( J:177557 )

decreased body weight ( J:177557 )

postnatal growth retardation ( J:177557 )

increased spleen weight ( J:177557 )

immune system

increased spleen weight ( J:177557 )

decreased osteoclast cell number ( J:177557 )

• not detected

craniofacial

failure of tooth eruption ( J:177557 )

hematopoietic system

increased spleen weight ( J:177557 )

decreased osteoclast cell number ( J:177557 )

• not detected

Genotype
MGI:5297088

ht2

• Allelic Composition: Tnfsf11^tm1.2Htaka/Tnfsf11⁺
• Genetic Background: B6.Cg-Tnfsf11^tm1.2Htaka

skeleton

decreased osteoclast cell number ( J:177557 )

increased bone volume ( J:177557 )

abnormal trabecular bone morphology ( J:177557 )

• trabecular separation is decreased compared to in wild-type mice

immune system

decreased osteoclast cell number ( J:177557 )

hematopoietic system

decreased osteoclast cell number ( J:177557 )

Genotype
MGI:5297085

cn3

• Allelic Composition: Tnfsf11^tm1.1Htaka/Tnfsf11^tm1.2Htaka; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

skeleton

skeleton phenotype ( J:177557 )

N • mice do not exhibit an osteopetrotic phenotype unlike null mice

Genotype
MGI:5297086

cn4

• Allelic Composition: Tnfsf11^tm1.1Htaka/Tnfsf11^tm1.2Htaka; Tg(Dmp1-cre)1Jqfe/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

skeleton

skeleton phenotype ( J:177557 )

N • mice exhibit normal tooth eruption

decreased osteoclast cell number ( J:177557 )

increased bone volume ( J:177557 )

• at 12 weeks of age

increased trabecular bone volume ( J:177557 )

• filling the bone marrow cavity at 12 weeks of age

increased bone mass ( J:177557 )

• with age beginning postnatally

osteopetrosis ( J:177557 )

• severe postnatally

abnormal cartilage morphology ( J:177557 )

• mice exhibit cartilage remnants unlike control mice

abnormal bone ossification ( J:177557 )

• bone formation is decreased compared to in control mice

decreased bone resorption ( J:177557 )

immune system

decreased osteoclast cell number ( J:177557 )

growth/size/body

growth/size/body region phenotype ( J:177557 )

N • mice exhibit normal growth

hematopoietic system

decreased osteoclast cell number ( J:177557 )