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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfsf11tm1.1Htaka
targeted mutation 1.1, Hiroshi Takayanagi
MGI:5297060
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfsf11tm1.1Htaka/Tnfsf11tm1.1Htaka B6.Cg-Tnfsf11tm1.1Htaka MGI:5297084
cn2
 		Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka
Tg(Lck-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J MGI:5297085
cn3
 		Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka
Tg(Dmp1-cre)1Jqfe/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N MGI:5297086


Genotype
MGI:5297084
hm1
Allelic
Composition		 Tnfsf11tm1.1Htaka/Tnfsf11tm1.1Htaka
Genetic
Background		 B6.Cg-Tnfsf11tm1.1Htaka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf11tm1.1Htaka mutation (0 available); any Tnfsf11 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:177557 )
N
• mice do not exhibit an osteopetrotic phenotype unlike null mice




Genotype
MGI:5297085
cn2
Allelic
Composition		 Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)1Cwi mutation (3 available)
Tnfsf11tm1.1Htaka mutation (0 available); any Tnfsf11 mutation (30 available)
Tnfsf11tm1.2Htaka mutation (0 available); any Tnfsf11 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:177557 )
N
• mice do not exhibit an osteopetrotic phenotype unlike null mice




Genotype
MGI:5297086
cn3
Allelic
Composition		 Tnfsf11tm1.1Htaka/Tnfsf11tm1.2Htaka
Tg(Dmp1-cre)1Jqfe/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dmp1-cre)1Jqfe mutation (9 available)
Tnfsf11tm1.1Htaka mutation (0 available); any Tnfsf11 mutation (30 available)
Tnfsf11tm1.2Htaka mutation (0 available); any Tnfsf11 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:177557 )
N
• mice exhibit normal tooth eruption
increased bone volume ( J:177557 )
• at 12 weeks of age
increased trabecular bone volume ( J:177557 )
• filling the bone marrow cavity at 12 weeks of age
increased bone mass ( J:177557 )
• with age beginning postnatally
osteopetrosis ( J:177557 )
• severe postnatally
abnormal cartilage morphology ( J:177557 )
• mice exhibit cartilage remnants unlike control mice
abnormal bone ossification ( J:177557 )
• bone formation is decreased compared to in control mice

immune system

growth/size/body
growth/size/body region phenotype ( J:177557 )
N
• mice exhibit normal growth

hematopoietic system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory