Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cttntm1.2Dvst mutation
(0 available);
any
Cttn mutation
(28 available)
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mortality/aging
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• Background Sensitivity: fewer than expected mice are produced from mating heterozygotes unlike mice on a mixed background
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reproductive system
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N |
• Background Sensitivity: male female ratio is normal unlike mice on a mixed background
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Allelic
Composition |
Cttntm1.2Dvst/Cttntm1.2Dvst
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Genetic
Background |
either: B6.Cg-Cttntm1.2Dvst or (involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2 * SJL) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cttntm1.2Dvst mutation
(0 available);
any
Cttn mutation
(28 available)
|
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immune system
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• increased rolling velocity and rolling flux fraction with reduced neutrophils adhered to endothelium
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• neutrophil extravasation through a monolayer of primary murine lung endothelial cells is reduced compared with wild-type cells
• however, neutrophil adhesion is normal and constitutively active RhoG restores neutrophil transmigration
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• reduced neutrophils adhesion to endothelium
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• increased rolling velocity and rolling flux fraction with reduced neutrophils adhered to endothelium
• neutrophil extravasation through a monolayer of primary murine lung endothelial cells is reduced compared with wild-type cells
• however, constitutively active RhoG restores neutrophil transmigration
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cardiovascular system
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• decrease diameter and increased wall shear rate
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• more than 2-fold in skin vasculature
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respiratory system
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• murine lung endothelial cells exhibit reduced contact integrity and increased higher permeability compared with wild-type cells
• however, lung endothelial cell permeability is restored by treatment with 007
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cellular
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• increased rolling velocity and rolling flux fraction with reduced neutrophils adhered to endothelium
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• neutrophil extravasation through a monolayer of primary murine lung endothelial cells is reduced compared with wild-type cells
• however, neutrophil adhesion is normal and constitutively active RhoG restores neutrophil transmigration
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• reduced neutrophils adhesion to endothelium
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hematopoietic system
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• increased rolling velocity and rolling flux fraction with reduced neutrophils adhered to endothelium
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• neutrophil extravasation through a monolayer of primary murine lung endothelial cells is reduced compared with wild-type cells
• however, neutrophil adhesion is normal and constitutively active RhoG restores neutrophil transmigration
|
|
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• reduced neutrophils adhesion to endothelium
|
|
|
• increased rolling velocity and rolling flux fraction with reduced neutrophils adhered to endothelium
• neutrophil extravasation through a monolayer of primary murine lung endothelial cells is reduced compared with wild-type cells
• however, constitutively active RhoG restores neutrophil transmigration
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cttntm1.2Dvst mutation
(0 available);
any
Cttn mutation
(28 available)
|
|
|
mortality/aging
|
N |
• Background Sensitivity: mice are produced at expected ratios unlike mice on a congenic C57BL/6 background
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reproductive system
|
|
• Background Sensitivity: preference towards female offspring unlike mice on a congenic C57BL/6 background
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cttntm1.2Dvst mutation
(0 available);
any
Cttn mutation
(28 available)
|
|
|
mortality/aging
|
|
• Background Sensitivity: fewer than expected mice are produced from mating heterozygotes unlike mice on a mixed background
|
Analysis Tools