Cttn^tm1.2Dvst
Targeted Allele Detail

Summary

• Symbol: Cttn^tm1.2Dvst
• Name: cortactin; targeted mutation 1.2, Dietmar Vestweber
• MGI ID: MGI:5296621
• Synonyms: Cttn^del
• Gene: Cttn Location: Chr7:143989468-144024743 bp, - strand Genetic Position: Chr7, 88.84 cM
• Alliance: Cttn^tm1.2Dvst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177602
• Parent Cell Line: IDG3.2 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed exon 7. The absence of protein expression was confirmed by immunoblotting. (J:177602)

Generation of the Cttn^tm1.1Dvst and Cttn^tm1.2Dvst alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cttn Mutation: 28 strains or lines available

References

• Original: J:177602 Schnoor M, et al., Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo. J Exp Med. 2011 Aug 1;208(8):1721-35
• All: 4 reference(s)