Phenotypes associated with this allele

• Allele Symbol: Xcl1^tm1.1Dnax
• Allele Name: targeted mutation 1.1, DNAX Research Institute of Cellular and Molecular Biology
• Allele ID: MGI:5296620
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xcl1^tm1.1Dnax/Xcl1^tm1.1Dnax	either: (involves: 129/Sv * BALB/c) or (involves: 129/Sv * C57BL/6)	MGI:5296657

Genotype
MGI:5296657

hm1

• Allelic Composition: Xcl1^tm1.1Dnax/Xcl1^tm1.1Dnax
• Genetic Background: either: (involves: 129/Sv * BALB/c) or (involves: 129/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune system morphology ( J:176844 )

decreased dendritic cell number ( J:176844 )

• reduced population of CD11c⁺ thymic dendritic cells in the thymus medullary region

• absolute number of thymic dendritic cells is unaffected

increased dendritic cell number ( J:176844 )

• significantly elevated in deep cortical regions of the thymus

• absolute number of thymic dendritic cells is unaffected

decreased regulatory T cell number ( J:176844 )

• reduced numbers of natural T reg cells in the thymus

autoimmune response ( J:176844 )

• autoimmune deposits in heart, liver, stomach, salivary, and lacrimal glands at 12-18 months

increased inflammatory response ( J:176844 )

• at 12 to 18 months of age

heart inflammation ( J:176844 )

salivary gland inflammation ( J:176844 )

stomach inflammation ( J:176844 )

lacrimal gland inflammation ( J:176844 )

liver inflammation ( J:176844 )

cardiovascular system

heart inflammation ( J:176844 )

digestive/alimentary system

salivary gland inflammation ( J:176844 )

stomach inflammation ( J:176844 )

endocrine/exocrine glands

salivary gland inflammation ( J:176844 )

lacrimal gland inflammation ( J:176844 )

liver/biliary system

liver inflammation ( J:176844 )

vision/eye

lacrimal gland inflammation ( J:176844 )

hematopoietic system

decreased dendritic cell number ( J:176844 )

• reduced population of CD11c⁺ thymic dendritic cells in the thymus medullary region

• absolute number of thymic dendritic cells is unaffected

increased dendritic cell number ( J:176844 )

• significantly elevated in deep cortical regions of the thymus

• absolute number of thymic dendritic cells is unaffected

decreased regulatory T cell number ( J:176844 )

• reduced numbers of natural T reg cells in the thymus