All Phenotypes Fat3<tm1.2Good> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fat3^tm1.2Good
targeted mutation 1.2, Lisa Goodrich
MGI:5295415

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fat3^tm1.2Good/Fat3^tm1.2Good	involves: 129P2/OlaHsd	MGI:5295429
cn2	Fat3^tm1.1Good/Fat3^tm1.2Good Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:5295430
cn3	Fat3^tm1.2Good/Fat3^tm1.2Good Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Tg(CAG-Bgeo/GFP)21Lbe/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5295428
cx4	Fat3^tm1.2Good/Fat3^tm1.2Good Atoh7^tm3(cre)Gan/Atoh7^tm3(cre)Gan	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:5295431
cx5	Fat3^tm1.2Good/Fat3^tm1.2Good Fjx1^tm1Awp/Fjx1^tm1Awp	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:5295432
cx6	Fat3^tm1.2Good/Fat3⁺ Fjx1^tm1Awp/Fjx1^tm1Awp	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:5295433
cx7	Fat3^tm1.2Good/Fat3^tm1.2Good Tg(Thy1-YFP)HJrs/0	involves: 129P2/OlaHsd * C57BL/6J * CBA	MGI:5295427

Allelic Composition	Fat3^tm1.2Good/Fat3^tm1.2Good
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fat3^tm1.2Good mutation (0 available); any Fat3 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:176668 )

N	• retinas exhibit normal planar cell polarity

abnormal retina morphology ( J:176668 )

• mice exhibit a disruption in the distribution of glycinergic amacrine cells and starburst cells

abnormal amacrine cell morphology ( J:176668 )

• amacrine cells are mislocalized in the ganglion cell layers

• fewer calretinin+ amacrine cells are found in the inner nuclear layer compared to in wild-type mice

• All amacrine cells are mispositioned within the inner nuclear layer

abnormal retina rod bipolar cell morphology ( J:176668 )

• rod bipolar cells frequently overshoot the inner plexiform layer and form ectopic endings in the nerve fiber layer

abnormal retina neuronal layer morphology ( J:176668 )

• amacrine cells form two additional plexiform layers (inner and outer misplaced plexiform layers) compared with wild-type mice

thick retina ganglion layer ( J:176668 )

• due to displaced amacrine cells

nervous system

abnormal amacrine cell morphology ( J:176668 )

• amacrine cells are mislocalized in the ganglion cell layers

• fewer calretinin+ amacrine cells are found in the inner nuclear layer compared to in wild-type mice

• All amacrine cells are mispositioned within the inner nuclear layer

abnormal retina rod bipolar cell morphology ( J:176668 )

• rod bipolar cells frequently overshoot the inner plexiform layer and form ectopic endings in the nerve fiber layer

Allelic Composition	Fat3^tm1.1Good/Fat3^tm1.2Good Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fat3^tm1.1Good mutation (1 available); any Fat3 mutation (240 available)
Fat3^tm1.2Good mutation (0 available); any Fat3 mutation (240 available)
Ptf1a^{tm1.1(cre)Cvw} mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina neuronal layer morphology ( J:176668 )

• amacrine cells form an additional plexiform layers (outer misplaced plexiform layers) compared with wild-type mice

• amacrine cells develop bipolar morphologies

• however, amacrine cell migration is normal and no inner misplaced plexiform layer is formed

Allelic Composition	Fat3^tm1.2Good/Fat3^tm1.2Good Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fat3^tm1.2Good mutation (0 available); any Fat3 mutation (240 available)
Ptf1a^{tm1.1(cre)Cvw} mutation (1 available); any Ptf1a mutation (30 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal amacrine cell morphology ( J:176668 )

• amacrine cells retain two processes after reaching the inner plexiform layer unlike unipolar wild-type cells

• amacrine cells fail to retract trailing processes upon reaching the inner plexiform layer

• amacrine cells develop a second arbor that extends to the outer misplaced plexiform layer

vision/eye

abnormal amacrine cell morphology ( J:176668 )

• amacrine cells retain two processes after reaching the inner plexiform layer unlike unipolar wild-type cells

• amacrine cells fail to retract trailing processes upon reaching the inner plexiform layer

• amacrine cells develop a second arbor that extends to the outer misplaced plexiform layer

abnormal retina neuronal layer morphology ( J:176668 )

• amacrine cells form two additional plexiform layers (inner and outer misplaced plexiform layers) compared with wild-type mice

Allelic Composition	Fat3^tm1.2Good/Fat3^tm1.2Good Atoh7^tm3(cre)Gan/Atoh7^tm3(cre)Gan
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm3(cre)Gan mutation (0 available); any Atoh7 mutation (9 available)
Fat3^tm1.2Good mutation (0 available); any Fat3 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina neuronal layer morphology ( J:176668 )

• amacrine cells form two additional plexiform layers (inner and outer misplaced plexiform layers) compared with wild-type mice

Allelic Composition	Fat3^tm1.2Good/Fat3^tm1.2Good Fjx1^tm1Awp/Fjx1^tm1Awp
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fat3^tm1.2Good mutation (0 available); any Fat3 mutation (240 available)
Fjx1^tm1Awp mutation (0 available); any Fjx1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:176668 )

N	• no ectopic plexiform layers form and Bhlhb5+ amacrine cell distribution is normal

Allelic Composition	Fat3^tm1.2Good/Fat3⁺ Fjx1^tm1Awp/Fjx1^tm1Awp
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina neuronal layer morphology ( J:176668 )

• mice exhibit a thin VGAT+ outer misplaced plexiform layer in the periphery of the ventral retina

• however, no inner misplaced plexiform layer forms

Allelic Composition	Fat3^tm1.2Good/Fat3^tm1.2Good Tg(Thy1-YFP)HJrs/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fat3^tm1.2Good mutation (0 available); any Fat3 mutation (240 available)
Tg(Thy1-YFP)HJrs mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal amacrine cell morphology ( J:176668 )

• at P3 with ectopic neurites extending towards the outer retina

vision/eye

abnormal amacrine cell morphology ( J:176668 )

• at P3 with ectopic neurites extending towards the outer retina

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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