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Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm1(RNU6-RNAi:Rad18)Wbaa targeted mutation 1, Willy M Baarends MGI:5295281 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 5-fold increased in aberrant elongating spermatid heads
• spermatids exhibit an increase in di-methylation of histone H3 Lys4 compared with control cells
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• at 4 and 19 weeks
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• reduced XY synapsis in spermatocytes
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• at 4 and 19 weeks
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• to a greater degree when heterozygotes are mated
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• at 4 weeks but not 19 weeks
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• 5-fold increased in aberrant elongating spermatid heads
• spermatids exhibit an increase in di-methylation of histone H3 Lys4 compared with control cells
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• spermatocytes exhibit persistent double-strand DNA breaks in meiotic prophase unlike in control cells
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• spermatocytes exhibit persistent double-strand DNA breaks in meiotic prophase unlike in control cells
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• at 4 and 19 weeks
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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