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Allele Symbol Allele Name Allele ID |
Tg(tetO-APPSwInd)Dbo transgene insertion, David R Borchelt MGI:5295154 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show virtually no detectable focal signals when presented with the an array of odors, suggesting loss of olfactory function
• administration of doxycycline from 3 to 4 weeks of age, results in modest odor-induced SpH-signals, while administration for 3 weeks, further restores odor-induced signals, with more glomeruli activated by odors
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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• no obvious Olfr17+ axonal convergence is seen in the olfactory bulb
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
|
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
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• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
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• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
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• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
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• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
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• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
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• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
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• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
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• structure of the olfactory bulb is altered
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• the glomerular layer is thinner, with a massive loss of glomeruli
• treatment with doxycycline restores the glomerular layer, although the glomerular layer appears disorganized
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• outer nerve layer is thinner
• increase in apoptosis in the outer nerve layer
• treatment with doxycycline restores the outer nerve layer
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• reduction in size of the olfactory bulb
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• mice show a reduction in VGlu2 staining, indicating loss of olfactory sensory neuron axon terminals in the olfactory bulb
• treatment with doxycycline restores these axon terminals in the olfactory bulb
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• neurodegeneration of olfactory sensory neurons, with most lost between 7 and 14 days of age
• treatment with doxycycline reverses neurodegeneration
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• rapid and widespread apoptosis in mature olfactory sensory neurons
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• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
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• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
|
|
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
|
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• rapid and widespread apoptosis in mature olfactory sensory neurons
|
|
• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
|
|
• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
|
|
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
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• rapid and widespread apoptosis in mature olfactory sensory neurons
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• in a buried food assay, mice take a longer time to find the cookie
• in an avoidance assay in which the simple odorant isovaleric acid is added to drinking water and becomes an aversive stimulus associated with an LiCl injection, the conditioned mutants show a higher preference for the odor-water than controls, indicating decreased ability to detect the odor
• administration of doxycycline restores odor detection in both the buried food assay and at high concentration of isovaleric acid in the avoidance assay
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:199798 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• olfactory epithelium is thinner in 3 week old mice
|
|
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
|
|
• olfactory epithelium is thinner in 3 week old mice
|
|
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
|
|
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
|
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• neurodegeneration of olfactory sensory neurons, with most lost before 7 days of age
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• apoptosis in olfactory sensory neurons
• basal stem cell proliferation in the olfactory epithelium is increased
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• olfactory epithelium is thinner in 3 week old mice
|
|
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
|
|
• apoptosis in olfactory sensory neurons
• basal stem cell proliferation in the olfactory epithelium is increased
|
|
• olfactory epithelium is thinner in 3 week old mice
|
|
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
|
|
• apoptosis in olfactory sensory neurons
• basal stem cell proliferation in the olfactory epithelium is increased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• activated microglia encapsulate amyloid beta plaques
• increase in the density of microglia surrounding plaques
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• mice show moderate and severe plaque burden at 6 and 11 months of age, respectively
• amyloid beta plaques displace neurons and axon initial segments such that axon initial segments frequently bend or take circuitous trajectories around, but seldom through, amyloid beta plaques
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• hypertrophic astrocytes are seen in the vicinity of plaques
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• occasionally axon initial segments traverse or are at the edges of plaques; these axon initial segments are fragmented, shorter, and thinner than those further away from the plaque
• decrease in the number of axon initial segments at 6 and 11 months of age
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• brains with heavy plaque burden have axons with random orientations and many dystrophic, degenerating axons, including axonal torpedoes
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• activated microglia encapsulate amyloid beta plaques
• increase in the density of microglia surrounding plaques
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• mice show moderate and severe plaque burden at 6 and 11 months of age, respectively
• amyloid beta plaques displace neurons and axon initial segments such that axon initial segments frequently bend or take circuitous trajectories around, but seldom through, amyloid beta plaques
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• activated microglia encapsulate amyloid beta plaques
• increase in the density of microglia surrounding plaques
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:236737 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• impaired BACE1 and late endosome retrograde transport
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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