Phenotypes associated with this allele

• Allele Symbol: Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}
• Allele Name: targeted mutation 3, George Q Daley
• Allele ID: MGI:5294613
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Col1a1^tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1^+	involves: 129S4/SvJae * C57BL/6	MGI:5569527
cn2	Col1a1^tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1^+ Myf5^tm1(cre)Mrc/Myf5^+	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5519077
cn3	Col1a1^tm2(tetO-LIN28B)Gqda/Col1a1^tm3(tetO-Mirlet7g/Mir21)Gqda Gt(ROSA)26Sor^tm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor^+ Wt1^tm2(cre/ERT2)Wtp/Wt1^+	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5638880
cx4	Col1a1^tm3(tetO-Mirlet7g/Mir21)Gqda/? Gt(ROSA)26Sor^tm1(rtTA*M2)Jae/Gt(ROSA)26Sor^+	involves: 129S4/SvJae * C57BL/6	MGI:5500065
cx5	Col1a1^tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1^+ Gt(ROSA)26Sor^tm1(rtTA*M2)Jae/Gt(ROSA)26Sor^+	involves: 129S4/SvJae * C57BL/6 * CD-1	MGI:5294615
cx6	Col1a1^tm2(tetO-LIN28B)Gqda/Col1a1^tm3(tetO-Mirlet7g/Mir21)Gqda Gt(ROSA)26Sor^tm1(rtTA*M2)Jae/Gt(ROSA)26Sor^+	involves: 129S4/SvJae * C57BL/6 * CD-1	MGI:5294616

Genotype
MGI:5569527

ht1

• Allelic Composition: Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/Col1a1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased neuronal stem cell self-renewal ( J:207231 )

• reduced multipotent neurospheres, neurosphere size and self-renewal potential in doxycycline-treated mice

Genotype
MGI:5519077

cn2

• Allelic Composition: Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/Col1a1⁺; Myf5^tm1(cre)Mrc/Myf5⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

growth/size/body

decreased body size ( J:199720 )

• dwarfism in male and female mice

decreased body length ( J:199720 )

Genotype
MGI:5638880

cn3

• Allelic Composition: Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}; Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺; Wt1^{tm2(cre/ERT2)Wtp}/Wt1⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

renal/urinary system

small kidney ( J:211179 )

• small kidney in mice induced with doxycycline from E14.5 until the end of the experiment

• however, cap mesenchyme differentiates normally in doxycycline induced mutants

Genotype
MGI:5500065

cx4

• Allelic Composition: Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/?; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

reproductive system

decreased primordial germ cell number ( J:196313 )

• in doxycycline-treated neonates

cellular

decreased primordial germ cell number ( J:196313 )

• in doxycycline-treated neonates

Genotype
MGI:5294615

cx5

• Allelic Composition: Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

growth/size/body

decreased body size ( J:177113 )

• following doxycycline treatment

postnatal growth retardation ( J:177113 )

• following doxycycline treatment

homeostasis/metabolism

increased circulating glucose level ( J:177113 )

• in the fed state following doxycycline treatment

increased circulating insulin level ( J:177113 )

• during a glucose tolerance test in doxycycline treated mice

• however, no difference in insulin sensitivity is detected following doxycycline treatment

impaired glucose tolerance ( J:177113 )

• following doxycycline treatment on a normal or high fat diet

Genotype
MGI:5294616

cx6

• Allelic Composition: Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:177113 )

N • following doxycycline treatment responses in a glucose tolerance test are similar to controls