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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc2a1tm1.1Stma
targeted mutation 1.1, Steven M Anderson
MGI:5293720
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Slc2a1tm1.1Stma/Slc2a1+
Tcrdtm1.1(cre/ERT2)Zhu/Tcrd+ 		involves: 129S1/Sv * C57BL/6J MGI:8449412
cn2
 		Slc2a1tm1.1Stma/Slc2a1tm1.1Stma
Tcrdtm1.1(cre/ERT2)Zhu/Tcrd+ 		involves: 129S1/Sv * C57BL/6J MGI:8449411


Genotype
MGI:8449412
cn1
Allelic
Composition		 Slc2a1tm1.1Stma/Slc2a1+
Tcrdtm1.1(cre/ERT2)Zhu/Tcrd+
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc2a1tm1.1Stma mutation (2 available); any Slc2a1 mutation (63 available)
Tcrdtm1.1(cre/ERT2)Zhu mutation (1 available); any Tcrd mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:327132 )
• tamoxifen-treated mice subjected to azoxymethane-dextran sodium sulfate (AOM-DSS) show a higher colon tumor number and load compared to wild-type mice, without affecting tumor size
• however, no reduction in tumor-infiltrating gamma-delta/alpha-beta cell ratio or in the frequency of Vgamma7+ cells is seen in tamoxifen-treated mice

hematopoietic system
abnormal T cell physiology ( J:327132 )
• tamoxifen-treated mice subjected to AOM-DSS show a reduction in IFN-gamma production by tumor-infiltrating gamma-delta T cells

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:327132 )
• tamoxifen-treated mice subjected to azoxymethane-dextran sodium sulfate (AOM-DSS) show a higher colon tumor number and load compared to wild-type mice, without affecting tumor size
• however, no reduction in tumor-infiltrating gamma-delta/alpha-beta cell ratio or in the frequency of Vgamma7+ cells is seen in tamoxifen-treated mice

immune system
abnormal T cell physiology ( J:327132 )
• tamoxifen-treated mice subjected to AOM-DSS show a reduction in IFN-gamma production by tumor-infiltrating gamma-delta T cells
decreased interferon-gamma secretion ( J:327132 )
• tamoxifen-treated mice subjected to AOM-DSS show a reduction in IFN-gamma production by tumor-infiltrating gamma-delta T cells
• however, the frequency of IFN-gamma production by TCRalpabeta+CD8alphabeta+ cells is unaffected




Genotype
MGI:8449411
cn2
Allelic
Composition		 Slc2a1tm1.1Stma/Slc2a1tm1.1Stma
Tcrdtm1.1(cre/ERT2)Zhu/Tcrd+
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc2a1tm1.1Stma mutation (2 available); any Slc2a1 mutation (63 available)
Tcrdtm1.1(cre/ERT2)Zhu mutation (1 available); any Tcrd mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell physiology ( J:327132 )
• tamoxifen-treated mice subjected to AOM-DSS show a reduction in IFN-gamma production by tumor-infiltrating gamma-delta T cells

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:327132 )
• tamoxifen-treated mice subjected to azoxymethane-dextran sodium sulfate (AOM-DSS) show a higher colon tumor number and load compared to wild-type mice, without affecting tumor size
• however, late tamoxifen-treatment (after the second DSS cycle) has no effect on tumor load or tumor-infiltrating gamma-delta T cells

immune system
abnormal T cell physiology ( J:327132 )
• tamoxifen-treated mice subjected to AOM-DSS show a reduction in IFN-gamma production by tumor-infiltrating gamma-delta T cells
decreased interferon-gamma secretion ( J:327132 )
• tamoxifen-treated mice subjected to AOM-DSS show a reduction in IFN-gamma production by tumor-infiltrating gamma-delta T cells
• however, the frequency of IFN-gamma production by TCRalpabeta+CD8alphabeta+ cells is unaffected

neoplasm
increased incidence of tumors by chemical induction ( J:327132 )
• tamoxifen-treated mice subjected to azoxymethane-dextran sodium sulfate (AOM-DSS) show a higher colon tumor number and load compared to wild-type mice, without affecting tumor size
• however, late tamoxifen-treatment (after the second DSS cycle) has no effect on tumor load or tumor-infiltrating gamma-delta T cells




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10/13/2026
MGI 6.29 		The Jackson Laboratory