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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cyldtm1.1Mpa
targeted mutation 1.1, Manolis Pasparakis
MGI:5293377
Summary 3 genotypes


Genotype
MGI:5293401
cn1
Allelic
Composition		 Cyldtm1.1Mpa/Cyldtm1.1Mpa
Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa
Tg(Vil1-cre)997Gum/0
Genetic
Background		 B6.Cg-Cyldtm1.1Mpa Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyldtm1.1Mpa mutation (0 available); any Cyld mutation (43 available)
Ikbkgtm1.1Mpa mutation (1 available); any Ikbkg mutation (15 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
colitis ( J:175865 )
• as in Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa Tg(Vil-cre)997Gum

endocrine/exocrine glands

immune system
colitis ( J:175865 )
• as in Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa Tg(Vil-cre)997Gum




Genotype
MGI:5293402
cn2
Allelic
Composition		 Cyldtm1.1Mpa/Cyldtm1.1Mpa
Ikbkgtm1.1Mpa/Y
Tg(Vil1-cre)997Gum/0
Genetic
Background		 B6.Cg-Cyldtm1.1Mpa Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyldtm1.1Mpa mutation (0 available); any Cyld mutation (43 available)
Ikbkgtm1.1Mpa mutation (1 available); any Ikbkg mutation (15 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
colitis ( J:175865 )
• as in Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa Tg(Vil-cre)997Gum

endocrine/exocrine glands

immune system
colitis ( J:175865 )
• as in Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa Tg(Vil-cre)997Gum




Genotype
MGI:5293400
cn3
Allelic
Composition		 Cyldtm1.1Mpa/Cyldtm1.1Mpa
Faddtm1Mpa/Faddtm1Mpa
Tg(Vil1-cre)997Gum/0
Genetic
Background		 B6.Cg-Faddtm1Mpa Cyldtm1.1Mpa Tg(Vil1-cre)997Gum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyldtm1.1Mpa mutation (0 available); any Cyld mutation (43 available)
Faddtm1Mpa mutation (0 available); any Fadd mutation (19 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:175865 )
N
• mice do not develop colitis
decreased Paneth cell number ( J:175865 )
• reduced numbers

endocrine/exocrine glands
decreased Paneth cell number ( J:175865 )
• reduced numbers

immune system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory