Phenotypes associated with this allele

• Allele Symbol: Prkab1^tm1Grst
• Allele Name: targeted mutation 1, Gregory R Steinberg
• Allele ID: MGI:5293373
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Prkab1^tm1Grst/Prkab1^tm1Grst Prkab2^tm1Grst/Prkab2^tm1Grst Tg(Ckmm-cre)5Khn/0	involves: C57BL/6 * FVB	MGI:5293380

Genotype
MGI:5293380

cn1

• Allelic Composition: Prkab1^tm1Grst/Prkab1^tm1Grst; Prkab2^tm1Grst/Prkab2^tm1Grst; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

decreased muscle cell glucose uptake ( J:176578 )

• decreased glucose uptake during exercise

abnormal skeletal muscle morphology ( J:176578 )

• decrease in intermyofibrillar mitochondrial content

• mitochondria in both the intermyofibrillar and subsarcolemmal regions are larger

increased muscle fatigability ( J:176578 )

• isolated EDL muscles fatigue rapidly

behavior/neurological

decreased locomotor activity ( J:176578 )

• decrease in voluntary wheel activity

impaired exercise endurance ( J:176578 )

• exercise intolerant and have dramatic reductions in both maximal running speed and distance covered

homeostasis/metabolism

impaired exercise endurance ( J:176578 )

• exercise intolerant and have dramatic reductions in both maximal running speed and distance covered

increased circulating glucose level ( J:176578 )

• elevated serum glucose following exercise

abnormal enzyme/coenzyme activity ( J:176578 )

• decrease in citrate synthase and cytochrome c oxidase activities

cellular

decreased muscle cell glucose uptake ( J:176578 )

• decreased glucose uptake during exercise