Phenotypes associated with this allele

• Allele Symbol: Gcm2^tm1Hoso
• Allele Name: targeted mutation 1, Toshihiko Hosoya
• Allele ID: MGI:5292469
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gcm2^tm1Hoso/Gcm2^tm1Hoso	either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)	MGI:5292471
cx2	Gcm1^tm1Hoso/Gcm1^tm1Hoso Gcm2^tm1Hoso/Gcm2^tm1Hoso	either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)	MGI:5292472

Genotype
MGI:5292471

hm1

• Allelic Composition: Gcm2^tm1Hoso/Gcm2^tm1Hoso
• Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:175891 )

• fewer than expected mice are present at E8.5 to E9.5

nervous system

abnormal neuron differentiation ( J:175891 )

• neural stem cell induction is impaired

incomplete rostral neuropore closure ( J:175891 )

decreased brain size ( J:175891 )

• at E10.5 in 9 of 12 mice

cellular

abnormal neuron differentiation ( J:175891 )

• neural stem cell induction is impaired

abnormal DNA methylation ( J:175891 )

• at E8.33, demethylation of the Hes5 promoter is impaired

embryo

incomplete rostral neuropore closure ( J:175891 )

Genotype
MGI:5292472

cx2

• Allelic Composition: Gcm1^tm1Hoso/Gcm1^tm1Hoso; Gcm2^tm1Hoso/Gcm2^tm1Hoso
• Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:175891 )

nervous system

abnormal neuron differentiation ( J:175891 )

• neural stem cell induction is impaired

cellular

abnormal neuron differentiation ( J:175891 )

• neural stem cell induction is impaired

abnormal DNA methylation ( J:175891 )

• at E8.33, demethylation of the Hes5 promoter is impaired