Phenotypes associated with this allele

• Allele Symbol: Grin2a^tm1.1Ppao
• Allele Name: targeted mutation 1.1, Pierre Paoletti
• Allele ID: MGI:5292331
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2a^tm1.1Ppao/Grin2a^tm1.1Ppao	involves: 129 * C57BL/6	MGI:5292337

Genotype
MGI:5292337

hm1

• Allelic Composition: Grin2a^tm1.1Ppao/Grin2a^tm1.1Ppao
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:175900 )

N • chronic pain-induced heat hyperalgesia is normal

decreased chemical nociceptive threshold ( J:175900 )

• hypersensitive to capsaicin but not TIP39

decreased chemically-elicited antinociception ( J:175900 )

• zinc treatment fails to relieve pain in complete Freund's adjuvant and sciatic nerve ligation pain models unlike in similarly treated wild-type mice

allodynia ( J:175900 )

• amplitude and duration of mechanical allodynia is increased in response to both complete Freund's adjuvant and sciatic nerve ligation compared to in wild-type mice

decreased thermal nociceptive threshold ( J:175900 )

• hypersensitive to radiant heat or slow heat pain stimuli

nervous system

abnormal excitatory postsynaptic currents ( J:175900 )

• barely affected by submicromolar zinc application