Grin2a^tm1.1Ppao
Targeted Allele Detail

Summary

• Symbol: Grin2a^tm1.1Ppao
• Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1.1, Pierre Paoletti
• MGI ID: MGI:5292331
• Synonyms: NR2A^H128S, NR2A-H128S
• Gene: Grin2a Location: Chr16:9385762-9813424 bp, - strand Genetic Position: Chr16, 5.28 cM
• Alliance: Grin2a^tm1.1Ppao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175900
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 1 was replaced with a modified exon 1 in which nucleotide substitutions (CAT to TCC) result in the amino acid substitution of serine for histidine at position 128 (H128S). A floxed neo cassette inserted downstream of the modified exon 1 was removed by cre-mediated recombination. (J:175900)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin2a Mutation: 66 strains or lines available

References

• Original: J:175900 Nozaki C, et al., Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit. Nat Neurosci. 2011 Aug;14(8):1017-22
• All: 3 reference(s)