Phenotypes associated with this allele

• Allele Symbol: Tnfaip3^tm1.1Awai
• Allele Name: targeted mutation 1.1, Ari Waisman
• Allele ID: MGI:5291646
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd19^tm1(cre)Cgn/Cd19^+ Tnfaip3^tm1.1Awai/Tnfaip3^tm1.1Awai	involves: 129P2/OlaHsd	MGI:5291647

Genotype
MGI:5291647

cn1

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Tnfaip3^tm1.1Awai/Tnfaip3^tm1.1Awai
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell proliferation ( J:175422 )

enlarged spleen ( J:175422 )

decreased mature B cell number ( J:175422 )

• in the bone marrow

decreased B-1a cell number ( J:175422 )

decreased B-1b cell number ( J:175422 )

decreased marginal zone B cell number ( J:175422 )

increased B cell number ( J:175422 )

• in the spleen and lymph nodes

increased germinal center B cell number ( J:175422 )

• in mesenteric lymph nodes and Peyer's patches

increased follicular B cell number ( J:175422 )

increased T cell number ( J:175422 )

• in the spleen and lymph nodes

increased splenocyte number ( J:175422 )

increased IgA level ( J:175422 )

increased IgG2a level ( J:175422 )

• in unstimulated and NP-CG-stimulated mice

increased IgM level ( J:175422 )

• in unstimulated and NP-CG-stimulated mice

increased anti-nuclear antigen antibody level ( J:175422 )

hematopoietic system

increased B cell proliferation ( J:175422 )

enlarged spleen ( J:175422 )

decreased mature B cell number ( J:175422 )

• in the bone marrow

decreased B-1a cell number ( J:175422 )

decreased B-1b cell number ( J:175422 )

decreased marginal zone B cell number ( J:175422 )

increased B cell number ( J:175422 )

• in the spleen and lymph nodes

increased germinal center B cell number ( J:175422 )

• in mesenteric lymph nodes and Peyer's patches

increased follicular B cell number ( J:175422 )

increased T cell number ( J:175422 )

• in the spleen and lymph nodes

increased splenocyte number ( J:175422 )

increased IgA level ( J:175422 )

increased IgG2a level ( J:175422 )

• in unstimulated and NP-CG-stimulated mice

increased IgM level ( J:175422 )

• in unstimulated and NP-CG-stimulated mice

growth/size/body

enlarged spleen ( J:175422 )

cellular

increased B cell proliferation ( J:175422 )