Phenotypes associated with this allele

• Allele Symbol: Mterf4^tm1.1Lrsn
• Allele Name: targeted mutation 1.1, Nils-Goran Larsson
• Allele ID: MGI:5288505
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mterf4^tm1.1Lrsn/Mterf4^tm1.1Lrsn Tg(Ckmm-cre)5Khn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB	MGI:5292478

Genotype
MGI:5292478

cn1

• Allelic Composition: Mterf4^tm1.1Lrsn/Mterf4^tm1.1Lrsn; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:175816 )

• maximal life span is shortened to 21 weeks

cardiovascular system

abnormal myocardial fiber morphology ( J:175816 )

• gradual accumulation of mitochondria with abnormal morphology in the myocardium from 5 weeks of age onwards

enlarged heart ( J:175816 )

• gradual increase in absolute and relative heart size with age

abnormal myocardial fiber physiology ( J:175816 )

• levels of assembled complexes containing mtDNA-encoded subunits are decreased from 5 weeks of age onward

• severe respiratory chain deficiency

cardiomyopathy ( J:175816 )

• severe mitochondrial cardiomyopathy develops from 5 weeks of age onwards

cellular

abnormal mitochondrial physiology ( J:175816 )

• severe decrease of in organello translation in the hearts

growth/size/body

enlarged heart ( J:175816 )

• gradual increase in absolute and relative heart size with age

decreased body weight ( J:175816 )

• from 15 weeks of age

muscle

abnormal myocardial fiber morphology ( J:175816 )

• gradual accumulation of mitochondria with abnormal morphology in the myocardium from 5 weeks of age onwards

cardiomyopathy ( J:175816 )

• severe mitochondrial cardiomyopathy develops from 5 weeks of age onwards